Role of secretomes in cell-free therapeutic strategies in regenerative medicine

A Karimian, SM Khoshnazar, T Kazemi, A Asadi… - Cell and Tissue …, 2023 - Springer
After an injury, peripheral nervous system neurons have the potential to rebuild their axons
by generating a complicated activation response. Signals from the damaged axon are …

Depressed Protein Synthesis and Anabolic Signaling Potentiate ACL Tear–Resultant Quadriceps Atrophy

AR Keeble, CR Brightwell, CM Latham… - … American journal of …, 2023 - journals.sagepub.com
Background: Anterior cruciate ligament (ACL) tear (ACLT) leads to protracted quadriceps
muscle atrophy. Protein turnover largely dictates muscle size and is highly responsive to …

Mechanotherapy reprograms aged muscle stromal cells to remodel the extracellular matrix during recovery from disuse

ZR Hettinger, Y Wen, BD Peck, K Hamagata… - Function, 2022 - academic.oup.com
Aging is accompanied by reduced remodeling of skeletal muscle extracellular matrix (ECM),
which is exacerbated during recovery following periods of disuse atrophy. Mechanotherapy …

Stem cell secretome treatment improves whole‐body metabolism, reduces adiposity, and promotes skeletal muscle function in aged mice

ZJ Fennel, PE Bourrant, AS Kurian, JJ Petrocelli… - Aging …, 2024 - Wiley Online Library
Aging coincides with the progressive loss of muscle mass and strength, increased adiposity,
and diminished physical function. Accordingly, interventions aimed at improving muscle …

Palmitate-Induced Inflammation and Myotube Atrophy in C2C12 Cells Are Prevented by the Whey Bioactive Peptide, Glycomacropeptide

NMMP de Hart, JJ Petrocelli, RJ Nicholson… - The Journal of …, 2023 - Elsevier
Background Metabolic diseases are often associated with muscle atrophy and heightened
inflammation. The whey bioactive compound, glycomacropeptide (GMP), has been shown to …

Muscle disuse as hindlimb unloading in early postnatal mice negatively impacts grip strength in adult mice: a pilot study

PT Reidy, AD Smith, BE Jevnikar… - Journal of Applied …, 2023 - journals.physiology.org
Physical inactivity has many detrimental effects on health, yet the impact of physical inactivity
in early life on muscle health in adulthood remains unknown. Early postnatal malnutrition …

[HTML][HTML] Skeletal Muscle Stem Cells in Aging: Asymmetric/Symmetric Division Switching

E Manole, G Gaina, LC Ceafalan, ME Hinescu - Symmetry, 2022 - mdpi.com
In aged muscle, satellite cells' symmetric and asymmetric divisions are impaired, and
intrinsic and extrinsic complex mechanisms govern these processes. This review presents …

A Network Meta-Analysis of Sarcopenia Characteristic Indicators in Different Mouse Models of Muscular Dystrophy

Q Jiang, Z Geng, N Wang, Y Long, G Yang, P Wang… - 2024 - researchsquare.com
Objective Through a systematic review, compare the differences in characteristic indicators
of muscle atrophy in commonly used mouse models, including muscle mass, muscle …

[HTML][HTML] Industry updates from the field of stem cell research and regenerative medicine in October 2023

D Ilic, M Liovic - Regenerative medicine, 2024 - Taylor & Francis
Industry updates from the field of stem cell research and regenerative medicine in October
2023 | Regenerative Medicine Future Medicine Logo Search This Journal Anywhere Quick …