Simple Summary Three-dimensional (3D) cell culture models have been proposed as
alternatives for initial drug screening to increase drug development efficiency. In addition to …

Abstract Three-dimensional (3D) cell culture has tremendous advantages to closely mimic
the in vivo architecture and microenvironment of healthy tissue and organs, as well as of …

Biohybrid bacteria–based microrobots are increasingly recognized as promising externally
controllable vehicles for targeted cancer therapy. Magnetic fields in particular have been …

N6-methyladenosine modification is the most common RNA modification mechanism in
mammals. YTHDF1, a m6A reader, can recognize the m6A of mRNAs to facilitate the …

Cancer metastasis depends on cell survival following loss of extracellular matrix attachment
and dissemination through the circulation. The metastatic spread can be enhanced by the …

Although metastatic melanoma can be managed with chemotherapy, its heterogeneity and
resistance to therapy remain poorly understood. In addition to the spread of melanoma in the …

The exact mechanistic understanding of cancer metastasis continues to be unknown,
although it is a major cause of death worldwide. Along with the tumor mass, the tumor …

Simple Summary It was found that long-established tumor-derived cell lines do not
adequately reproduce drug sensitivity and behavior of a real human cancers. Therefore …

Transient receptor potential (TRP) channels are one primary type of calcium (Ca 2+)
permeable channels, and those relevant transmembrane and intracellular TRP channels …

Limited blood supply and rapid tumor metabolism within solid tumors leads to nutrient
starvation, waste product accumulation and the generation of pH gradients across the tumor …