Functional recovery from peripheral nerve injury and repair depends on a multitude of
factors, both intrinsic and extrinsic to neurons. Neuronal survival after axotomy is a …

Damage to the central nervous system (CNS) elicits the activation of both astrocytes and
microglia. This review is focused on the principal features that characterize the activation of …

Interest in the role of peptides in the nervous system was sparked 20 years ago when
Guillemin, Schally, and their colleagues first identified the peptidergic nature of the …

Experimental models such as the facial nerve axotomy paradigm in rodents allow the
systematic and detailed study of the response of neurones and their microenvironment to …

Numerous attempts have been made to enhance and/or accelerate the recovery of injured
peripheral nerves. One of the methods studied is the use of phototherapy (low power laser …

Transection of the rat facial nerve leads to a rapid activation of both astrocytes and microglia
around axotomized motoneurons. The factors involved in glial activation in vivo are poorly …

The lipopolysaccharide (LPS) constituents of the gram-negative bacterial wall are among
the most potent activators of inflammation. In the current study, we examined the effect of …

Glial‐cell‐line–derived neurotrophic factor (GDNF) has been identified as a potent survival
and differentiation factor for several neuronal populations in the central nervous system …

Neuropeptides in dorsal root ganglia (DRG) have been implicated in the pathogenesis of
pain and neurogenic inflammation in experimental and clinical arthritis. Recently we …

Results A 10-fold increase (P< 0.0001) in mRNA for α-CGRP at 11 days post-transection
and an almost threefold increase (P< 0.0001) in neuronal survival at 6–9 months post …