Anhedonia—the loss of pleasure or lack of reactivity to pleasurable stimuli—remains a
formidable treatment challenge across neuropsychiatric disorders. In major depressive …

This theoretical article revives a classical bridging construct, canalization, to describe a new
model of a general factor of psychopathology. To achieve this, we have distinguished …

Intravenous ketamine is posited to rapidly reverse depression by rapidly enhancing
neuroplasticity. In human patients, we quantified gray matter microstructural changes on a …

Background The serotonin hypothesis of depression proposes that diminished serotonergic
(5-HT) neurotransmission is causal in the pathophysiology of the disorder. Although the …

Chronic stress increases the risk of developing psychiatric disorders, including mood and
anxiety disorders. Although behavioral responses to repeated stress vary across individuals …

Aim: This study aims to develop new approaches to characterize brain networks to
potentially contribute to a better understanding of mechanisms involved in depression …

Abstract ARNSTEN, AFT, MKP Joyce and AC Roberts. The Aversive Lens: Stress effects on
the prefrontal-cingulate cortical pathways that regulate emotion. NEUROSCI BIOBEHAV …

Ketamine, functioning as a channel blocker of the excitatory glutamate-gated N-methyl-d-
aspartate (NMDA) receptors, displays compelling fast-acting and sustained antidepressant …

Introduction Prefrontal transcranial direct current stimulation (tDCS) shows promise as an
effective treatment for depression. However, factors influencing treatment and the time …

Although pain-related excessive fear is known to be a key factor in chronic pain disability,
which involves the anterior cingulate cortex (ACC), little is known about the downstream …