The role of pontin and reptin in cellular physiology and cancer etiology
YQ Mao, WA Houry - Frontiers in molecular biosciences, 2017 - frontiersin.org
Pontin (RUVBL1, TIP49, TIP49a, Rvb1) and Reptin (RUVBL2, TIP48, TIP49b, Rvb2) are
highly conserved ATPases of the AAA+ (ATPases Associated with various cellular Activities) …
highly conserved ATPases of the AAA+ (ATPases Associated with various cellular Activities) …
Ribosome abundance control via the ubiquitin–proteasome system and autophagy
Ribosomes are central to the life of a cell, as they translate the genetic code into the amino
acid language of proteins. Moreover, ribosomal abundance within the cell is coordinated …
acid language of proteins. Moreover, ribosomal abundance within the cell is coordinated …
Resolution of R-loops by INO80 promotes DNA replication and maintains cancer cell proliferation and viability
L Prendergast, UL McClurg, R Hristova… - Nature …, 2020 - nature.com
Collisions between the DNA replication machinery and co-transcriptional R-loops can
impede DNA synthesis and are a major source of genomic instability in cancer cells. How …
impede DNA synthesis and are a major source of genomic instability in cancer cells. How …
DIP-MS: ultra-deep interaction proteomics for the deconvolution of protein complexes
Most proteins are organized in macromolecular assemblies, which represent key functional
units regulating and catalyzing most cellular processes. Affinity purification of the protein of …
units regulating and catalyzing most cellular processes. Affinity purification of the protein of …
The transcriptional coactivator RUVBL2 regulates Pol II clustering with diverse transcription factors
H Wang, B Li, L Zuo, B Wang, Y Yan, K Tian… - Nature …, 2022 - nature.com
Abstract RNA polymerase II (Pol II) apparatuses are compartmentalized into transcriptional
clusters. Whether protein factors control these clusters remains unknown. In this study, we …
clusters. Whether protein factors control these clusters remains unknown. In this study, we …
Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma
A hallmark of high-risk childhood medulloblastoma is the dysregulation of RNA translation.
Currently, it is unknown whether medulloblastoma dysregulates the translation of putatively …
Currently, it is unknown whether medulloblastoma dysregulates the translation of putatively …
The role of Hsp90-R2TP in macromolecular complex assembly and stabilization
J Lynham, WA Houry - Biomolecules, 2022 - mdpi.com
Hsp90 is a ubiquitous molecular chaperone involved in many cell signaling pathways, and
its interactions with specific chaperones and cochaperones determines which client proteins …
its interactions with specific chaperones and cochaperones determines which client proteins …
The PAQosome, an R2TP-based chaperone for quaternary structure formation
WA Houry, E Bertrand, B Coulombe - Trends in biochemical sciences, 2018 - cell.com
The Rvb1–Rvb2–Tah1–Pih1/prefoldin-like (R2TP/PFDL) complex is a unique chaperone
that provides a platform for the assembly and maturation of many key multiprotein …
that provides a platform for the assembly and maturation of many key multiprotein …
Tumor suppressor Tsc1 is a new Hsp90 co‐chaperone that facilitates folding of kinase and non‐kinase clients
The tumor suppressors Tsc1 and Tsc2 form the tuberous sclerosis complex (TSC), a
regulator of mTOR activity. Tsc1 stabilizes Tsc2; however, the precise mechanism involved …
regulator of mTOR activity. Tsc1 stabilizes Tsc2; however, the precise mechanism involved …
RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex
F Martino, M Pal, H Muñoz-Hernández… - Nature …, 2018 - nature.com
Abstract The R2TP/Prefoldin-like co-chaperone, in concert with HSP90, facilitates assembly
and cellular stability of RNA polymerase II, and complexes of PI3-kinase-like kinases such …
and cellular stability of RNA polymerase II, and complexes of PI3-kinase-like kinases such …