A growing preclinical and clinical body of work on the effects of chronic drug use and drug
addiction has extended the scope of inquiry from the putative reward-related subcortical …

Vascular insults can initiate a cascade of molecular events leading to neurodegeneration,
cognitive impairment, and dementia. Here, we review the cellular and molecular …

As the world endures the coronavirus disease 2019 (COVID-19) pandemic, the conditions of
35 million vulnerable individuals struggling with substance use disorders (SUDs) worldwide …

The blood–brain barrier (BBB) plays a crucial role in maintaining the specialized
microenvironment of the central nervous system (CNS). In aging, the stability of the BBB …

The dopamine (DA) precursor l-DOPA has been the most effective treatment for Parkinson's
disease (PD) for over 40 years. However, the response to this treatment changes with …

Objective: The aim of this study was to measure the protein concentration and biological
activity of HIV-1 Tat in cerebrospinal fluid (CSF) of individuals on suppressive antiretroviral …

The use of psychostimulants and alcohol disrupts blood-brain barrier (BBB) integrity,
resulting in alterations to cellular function, and contributes to neurotoxicity. The BBB is the …

Methamphetamine (METH) is a sympathomimetic amine that belongs to phenethylamine
and amphetamine class of psychoactive drugs, which are widely abused for their stimulant …

The blood‐brain barrier (BBB) regulates the transport of micro‐and macromolecules
between the peripheral blood and the central nervous system (CNS) in order to maintain …

Age is associated with increased risk for several disorders including dementias,
cardiovascular disease, atherosclerosis, obesity, and diabetes. Age is also associated with …