Many cellular processes require large-scale rearrangements of chromatin structure.
Structural maintenance of chromosomes (SMC) protein complexes are molecular machines …

Structural maintenance of chromosomes (SMC) complexes are key organizers of
chromosome architecture in all kingdoms of life. Despite seemingly divergent functions, such …

INTRODUCTION During mitosis, cells compact their chromosomes into dense rod-shaped
structures to ensure their reliable transmission to daughter cells. Our work explores how …

Loop extrusion by structural maintenance of chromosomes (SMC) complexes has been
proposed as a mechanism to organize chromatin in interphase and metaphase. However …

Structural maintenance of chromosomes (SMC) complexes are essential for genome
organization from bacteria to humans, but their mechanisms of action remain poorly …

Access to DNA is a prerequisite to the execution of essential cellular processes that include
transcription, replication, chromosomal segregation, and DNA repair. How the proteins that …

The two Condensin complexes in human cells are essential for mitotic chromosome
structure. We used homozygous genome editing to fluorescently tag Condensin I and II …

For cell division, negatively charged chromatin, in which nucleosome fibers (10 nm fibers)
are irregularly folded [1–5], must be condensed into chromosomes and segregated. While …

Our understanding of the structure and function of mitotic chromosomes has come a long
way since these iconic objects were first recognized more than 140 years ago, though many …

During mitosis, replicated chromosomes segregate such that each daughter cell receives
one copy of the genome. Faithful mechanical transport during mitosis requires that …