Gastric cancer (GC) ranks fifth in global cancer diagnosis and fourth in cancer-related death.
Despite tremendous progress in diagnosis and therapeutic strategies and significant …

Reprogramming of cellular metabolism is a hallmark of cancer. Cancer cells undergo
metabolic adaptations to maintain tumorigenicity and survive under the attack of immune …

Ferroptosis is a form of regulated cell death that is initiated by excessive lipid peroxidation
that results in plasma membrane damage and the release of damage-associated molecular …

Metastasis accounts for 90% of cancer-related deaths among the patients. The
transformation of epithelial cells into mesenchymal cells with molecular alterations can occur …

Abstract Stearoyl-CoA desaturase 1 (SCD1) converts saturated fatty acids to
monounsaturated fatty acids. The expression of SCD1 is increased in many cancers, and the …

Ferroptosis, a novel mode of cell death dependent on iron and reactive oxygen species, has
been extensively explored during malignant tumors metastasis. Ferroptosis can interact with …

Sorafenib, a small-molecule inhibitor targeting several tyrosine kinase pathways, is the
standard treatment for advanced hepatocellular carcinoma (HCC). However, not all patients …

Programmed cell death (PCD) plays an important role in many aspects of individual
development, maintenance of body homeostasis and pathological processes. Ferroptosis is …

Ferroptosis is a newly recognized form of oxidative-regulated cell death resulting from iron-
mediated lipid peroxidation accumulation. Radical-trapping antioxidant systems can …

As a novel form of regulated cell death, ferroptosis is characterized by intracellular iron and
lipid peroxide accumulation, which is different from other regulated cell death forms …