Antimicrobial-resistant ESKAPE (E nterococcus faecium, S taphylococcus aureus, K
lebsiella pneumoniae, A cinetobacter baumannii, P seudomonas aeruginosa, and E …

SUMMARY β-Lactam antibiotics have been widely used as therapeutic agents for the past
70 years, resulting in emergence of an abundance of β-lactam-inactivating β-lactamases …

Due to their superior tolerability and efficacy, β-lactams are the most potent and prescribed
class of antibiotics in the clinic. The emergence of resistance to those antibiotics, mainly due …

Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …

ABSTRACT β-Lactamases, the major resistance determinant for β-lactam antibiotics in Gram-
negative bacteria, are ancient enzymes whose origins can be traced back millions of years …

Resistance to β-lactam antibiotics in Gram-negative bacteria is commonly associated with
production of β-lactamases, including extended-spectrum β-lactamases (ESBLs) and …

Klebsiella pneumoniae is a Gram-negative pathogen that has a large accessory genome of
plasmids and chromosomal gene loci. This accessory genome divides K. pneumoniae …

Carbapenem-resistant Enterobacteriaceae (CRE) are a serious public health threat.
Infections due to these organisms are associated with significant morbidity and mortality …

Modern medicine is threatened by the global rise of antibiotic resistance, especially among
Gram-negative bacteria. Metallo-β-lactamase (MBL) enzymes are a particular concern and …

This chapter analyzes the epidemiology of Carbapenem-Resistant Enterobacteriaceae
(CRE) as well as current and future treatment options against the increasingly resistant …