Investigating the possible mechanisms of pirfenidone to be targeted as a promising anti-inflammatory, anti-fibrotic, anti-oxidant, anti-apoptotic, anti-tumor, and/or anti …
Pirfenidone (PFD) is a non-peptide synthetic chemical that inhibits the production of
transforming growth factor-beta 1 (TGF-β1), tumor necrosis factor-alpha (TNF-α), platelet …
transforming growth factor-beta 1 (TGF-β1), tumor necrosis factor-alpha (TNF-α), platelet …
Ligand-based design on the dog-bone-shaped BIBR1532 pharmacophoric features and synthesis of novel analogues as promising telomerase inhibitors with in vitro …
Telomerase is an outstanding biological target for cancer treatment. BIBR1532 is a non-
nucleoside selective telomerase inhibitor; however, it experiences ineligible …
nucleoside selective telomerase inhibitor; however, it experiences ineligible …
[HTML][HTML] Novel 4-thiophenyl-pyrazole, pyridine, and pyrimidine derivatives as potential antitumor candidates targeting both EGFR and VEGFR-2; design, synthesis …
SM Al-Muntaser, AA Al-Karmalawy, AM El-Naggar… - RSC …, 2023 - pubs.rsc.org
In this article, we continued our previous effort to develop new selective anticancer
candidates based on the basic pharmacophoric requirements of both EGFR and VEGFR-2 …
candidates based on the basic pharmacophoric requirements of both EGFR and VEGFR-2 …
[HTML][HTML] Synthesis of SARS-CoV-2 M pro inhibitors bearing a cinnamic ester warhead with in vitro activity against human coronaviruses
A Citarella, D Moi, M Pedrini, H Pérez-Peña… - Organic & …, 2023 - pubs.rsc.org
COVID-19 now ranks among the most devastating global pandemics in history. The
causative virus, SARS-CoV-2, is a new human coronavirus (hCoV) that spreads among …
causative virus, SARS-CoV-2, is a new human coronavirus (hCoV) that spreads among …
[HTML][HTML] Synthesis of new organoselenium-based succinanilic and maleanilic derivatives and in silico studies as possible SARS-CoV-2 main protease inhibitors
Herein we report the synthesis of organic selenide-based maleanilic and succinanilic acids
in good yields (up to 95%). Their structural identities were elucidated by spectroscopic …
in good yields (up to 95%). Their structural identities were elucidated by spectroscopic …
Investigating the potential anticancer activities of antibiotics as topoisomerase II inhibitors and DNA intercalators: in vitro, molecular docking, molecular dynamics, and …
Abstract Topoisomerase II (TOP-2) is a promising molecular target for cancer therapy.
Numerous antibiotics could interact with biologically relevant macromolecules and provoke …
Numerous antibiotics could interact with biologically relevant macromolecules and provoke …
Design and statistical optimisation of emulsomal nanoparticles for improved anti-SARS-CoV-2 activity of N-(5-nitrothiazol-2-yl)-carboxamido candidates: in vitro and in …
AA Al-Karmalawy, DS El-Gamil… - Journal of enzyme …, 2023 - Taylor & Francis
In this article, emulsomes (EMLs) were fabricated to encapsulate the N-(5-nitrothiazol-2-yl)-
carboxamido derivatives (3a–3g) in an attempt to improve their biological availability and …
carboxamido derivatives (3a–3g) in an attempt to improve their biological availability and …
[HTML][HTML] Some pyrimidohexahydroquinoline candidates: synthesis, DFT, cytotoxic activity evaluation, molecular docking, and in silico studies
SK Ramadan, HSM Abd-Rabboh, AAA Hafez… - RSC …, 2024 - pubs.rsc.org
Some hexahydroquinoline candidates were prepared by reacting 2-amino-3-cyano-1-
cyclohexylhexahydroquinoline with oxalyl chloride and triethyl orthoformate. The …
cyclohexylhexahydroquinoline with oxalyl chloride and triethyl orthoformate. The …
Biological evaluation, docking studies, and in silico ADME prediction of some pyrimidine and pyridine derivatives as potential EGFRWT and EGFRT790M inhibitors
Herein, a set of pyridine and pyrimidine derivatives were assessed for their impact on the
cell cycle and apoptosis. Human breast cancer (MCF7), hepatocellular carcinoma (HEPG2) …
cell cycle and apoptosis. Human breast cancer (MCF7), hepatocellular carcinoma (HEPG2) …
[HTML][HTML] Investigating the potential anti-SARS-CoV-2 and anti-MERS-CoV activities of yellow necklacepod among three selected medicinal plants: Extraction, isolation …
HI Abd-Alla, O Kutkat, HM Sweelam, WM Eldehna… - Metabolites, 2022 - mdpi.com
The anti-MERS-CoV activities of three medicinal plants (Azadirachta indica, Artemisia
judaica, and Sophora tomentosa) were evaluated. The highest viral inhibition percentage …
judaica, and Sophora tomentosa) were evaluated. The highest viral inhibition percentage …