The endothelium can evoke relaxations of the underlying vascular smooth muscle, by
releasing vasodilator substances. The best‐characterized endothelium‐derived relaxing …

Significance: The mitochondrial matrix contains much of the machinery at the heart of
metabolism. This compartment is also exposed to a high and continual flux of superoxide …

Necroptosis, necrosis and secondary necrosis following apoptosis represent different modes
of cell death that eventually result in similar cellular morphology including rounding of the …

Chronic reactive oxygen species (ROS) production by mitochondria may contribute to the
development of insulin resistance, a primary feature of type 2 diabetes. In recent years it has …

Macroautophagy (autophagy) is a crucial cellular stress response for degrading defective
macromolecules and organelles, as well as providing bioenergetic intermediates during …

Background—Excessive proliferation and impaired apoptosis of pulmonary artery (PA)
smooth muscle cells (PASMCs) contribute to vascular obstruction in patients and fawn …

Cell Science at a Glance 801 of a particular reactive oxygen species (ROS) or the shift in
redox state of a responsive group such as a dithiol–disulphide couple (D'Autreaux and …

The heme in the active center of peroxidases reacts with hydrogen peroxide to form highly
reactive intermediates, which then oxidize simple substances called peroxidase substrates …

The endothelium can evoke relaxations (dilatations) of the underlying vascular smooth
muscle, by releasing vasodilator substances. The best characterized endothelium-derived …

Abstract Aquaporin 3 (AQP3), a water/glycerol channel protein, has been found to transport
hydrogen peroxide (H2O2). Here, we show that H2O2, imported via AQP3, is involved in …