After ischaemic stroke, brain damage can be curtailed by rescuing the 'ischaemic penumbra'—
that is, the severely hypoperfused, at-risk but not yet infarcted tissue. Current evidence …

Several adverse events have been associated with the infusion of hemoglobin-based
oxygen carriers (HBOCs), including transient hypertension, gastrointestinal, pancreatic/liver …

The intraluminal filament model of middle cerebral artery occlusion (MCAO) in mice and rats
has been plagued by inconsistency, owing in part to the multitude of variables requiring …

The development of hemoglobin (Hb)-based oxygen carriers (HBOCs) has been hampered
because of safety concerns in humans. Chemical and/or genetic modifications of the Hb …

Two antithetic terms, hypoxia and hyperoxia, ie, insufficient and excess oxygen availability
with respect to needs, are thought to trigger opposite responses in cells and tissues. This …

Polymerization of deoxy sickle cell hemoglobin (HbS) is well recognized as the primary
event that triggers the classic cycles of sickling/unsickling of patients red blood cells (RBCs) …

Particle encapsulated hemoglobin (Hb)-based oxygen (O2) carriers (HBOCs) have clear
advantages over their acellular counterparts because of their larger molecular diameter and …

Historically, blood substitutes were under development that would provide oxygen carrying
capacity as well as fluid replacement for both trauma and surgical indications. Their …

PEG ylated carboxyhemoglobin bovine (SANGUINATE) is a dual action carbon monoxide
releasing (CO)/oxygen (O 2) transfer agent for the treatment of hypoxia. Its components …

Epoxyeicosatrienoic acids (EETs) are produced by cytochrome P450 epoxygenases from
arachidonic acid, and their rapid metabolism is mainly through soluble epoxide hydrolase …