Quantification of amyloid PET for future clinical use: a state-of-the-art review
Amyloid-β (Aβ) pathology is one of the earliest detectable brain changes in Alzheimer's
disease (AD) pathogenesis. The overall load and spatial distribution of brain Aβ can be …
disease (AD) pathogenesis. The overall load and spatial distribution of brain Aβ can be …
Longitudinal amyloid and tau PET imaging in Alzheimer's disease: A systematic review of methodologies and factors affecting quantification
Deposition of amyloid and tau pathology can be quantified in vivo using positron emission
tomography (PET). Accurate longitudinal measurements of accumulation from these images …
tomography (PET). Accurate longitudinal measurements of accumulation from these images …
Evaluation of tau deposition using 18F-PI-2620 PET in MCI and early AD subjects—a MissionAD tau sub-study
S Bullich, A Mueller, S De Santi, N Koglin… - Alzheimer's Research & …, 2022 - Springer
Background The ability of 18F-PI-2620 PET to measure the spatial distribution of tau
pathology in Alzheimer's disease (AD) has been demonstrated in previous studies. The …
pathology in Alzheimer's disease (AD) has been demonstrated in previous studies. The …
Association of Alzheimer's disease polygenic risk scores with amyloid accumulation in cognitively intact older adults
ES Luckett, Y Abakkouy, M Reinartz… - Alzheimer's Research & …, 2022 - Springer
Background Early detection of individuals at risk for Alzheimer's disease (AD) is highly
important. Amyloid accumulation is an early pathological AD event, but the genetic …
important. Amyloid accumulation is an early pathological AD event, but the genetic …
Strategies to reduce sample sizes in Alzheimer's disease primary and secondary prevention trials using longitudinal amyloid PET imaging
Background Detecting subtle-to-moderate biomarker changes such as those in amyloid PET
imaging becomes increasingly relevant in the context of primary and secondary prevention …
imaging becomes increasingly relevant in the context of primary and secondary prevention …
A dual-time-window protocol to reduce acquisition time of dynamic tau PET imaging using [18F]MK-6240
Abstract Background [18F] MK-6240 is a PET tracer with sub-nanomolar affinity for
neurofibrillary tangles. Therefore, tau quantification is possible with [18F] MK-6240 PET/CT …
neurofibrillary tangles. Therefore, tau quantification is possible with [18F] MK-6240 PET/CT …
[HTML][HTML] Parametric imaging of dual-time window [18F] flutemetamol and [18F] florbetaben studies
Optimal pharmacokinetic models for quantifying amyloid beta (Aβ) burden using both [18 F]
flutemetamol and [18 F] florbetaben scans have previously been identified at a region of …
flutemetamol and [18 F] florbetaben scans have previously been identified at a region of …
Early-phase 18F-FP-CIT and 18F-flutemetamol PET were significantly correlated
Little is known about whether early-phase PET images of 18F-FP-CIT match those of
amyloid PET. Here, we compared early-phase 18F-FP-CIT and 18F-flutemetamol PET …
amyloid PET. Here, we compared early-phase 18F-FP-CIT and 18F-flutemetamol PET …
Non-invasive quantification of 18F-florbetaben with total-body EXPLORER PET
Background Kinetic modeling of 18F-florbetaben provides important quantification of brain
amyloid deposition in research and clinical settings but its use is limited by the requirement …
amyloid deposition in research and clinical settings but its use is limited by the requirement …
The Early Perfusion Image Is Useful to Support the Visual Interpretation of Brain Amyloid-PET With 18F-Flutemetamol in Borderline Cases
Purpose Visual interpretation of brain amyloid-β (Aβ) PET can be difficult in individuals with
borderline Aβ burden. Coregistration with individual MRI is recommended in these cases …
borderline Aβ burden. Coregistration with individual MRI is recommended in these cases …