Evidence is emerging that the process of immune aging is a mechanism leading to
autoimmunity. Over lifetime, the immune system adapts to profound changes in …

Cellular homeostasis is continuously challenged by damage from reactive oxygen species
(ROS) and numerous reactive electrophiles. Human cells contain various protective systems …

Mitochondria are increasingly recognized as cellular hubs to orchestrate signaling pathways
that regulate metabolism, redox homeostasis, and cell fate decisions. Recent research …

Neutrophilia and the production of neutrophil extracellular traps (NETs) are two of many
measures of increased inflammation in severe COVID-19 that also accompany its …

Mitochondria are critical modulators of antiviral tolerance through the release of
mitochondrial RNA and DNA (mtDNA and mtRNA) fragments into the cytoplasm after …

Atherosclerosis (AS) is the main cause of cardiovascular disease (CVD) and is
characterized by endothelial damage, lipid deposition, and chronic inflammation. Gut …

Autoimmune cardiopathies (AC) following COVID-19 and vaccination against SARS-CoV-2
occur at significant rates but are of unknown etiology. This study investigated the possible …

Mitochondria retain bacterial traits due to their endosymbiotic origin, but host cells do not
recognize them as foreign because the organelles are sequestered. However, the regulated …

Vascular aging, a major risk factor for cardiovascular disease, contributes to morbidity and
mortality in older people. Mitochondria play an important role in vascular aging. In …

In humans, mitochondria play key roles in the regulation of cellular functions, such as the
regulation of the innate immune response and are targets of several pathogenic viruses and …