To help design needed new vaccines for pneumonic plague, we targeted the Yersinia pestis
LcrV protein directly to CD8α+ DEC‐205+ or CD8α− DCIR2+ DC along with a clinically …

Innate immunity plays a central role in resolving infections by pathogens. Host survival
during plague, caused by the Gram-negative bacterium Yersinia pestis, is favored by a …

Yersinia pestis, the causative agent of pneumonic plague, induces a highly lethal infection if
left untreated. Currently, there is no FDA-approved vaccine against this pathogen; however …

Plague caused by Yersinia pestis is one of the most dangerous infectious diseases. There is
no ideal plague vaccine available for human use, but a number of licensed killed whole-cell …

Plague is one of the most dangerous diseases and is caused by Yersinia pestis. Effective
vaccine development requires understanding of immune protective mechanisms against the …

All Yersinia species target and bind to phagocytic cells, but uptake and destruction of
bacteria are prevented by injection of anti-phagocytic Yop proteins into the host cell. Here …

Yersinia pestis is the causative agent of plague and is a re-emerging pathogen that also has
the potential as a biological weapon, necessitating the development of a preventive vaccine …

Vaccinating with live, conditionally attenuated, pigmentation (Pgm)-deficient Yersinia pestis
primes T cells that protect mice against pneumonic plague. However, Pgm-deficient strains …

We evaluated the possibility of using Yersinia pseudotuberculosis as a live vaccine against
plague because it shares high genetic identity with Y. pestis while being much less virulent …

We recently identified two virulence-associated small open reading frames (sORF) of
Yersinia pestis, named yp1 and yp2, and null mutants of each individual genes were highly …