The basic science of the subchondral bone

H Madry, CN van Dijk, M Mueller-Gerbl - Knee surgery, sports …, 2010 - Springer
In the past decades, considerable efforts have been made to propose experimental and
clinical treatments for articular cartilage defects. Yet, the problem of cartilage defects …

[HTML][HTML] Arthritis and the role of endogenous glucocorticoids

E Macfarlane, MJ Seibel, H Zhou - Bone research, 2020 - nature.com
Rheumatoid arthritis and osteoarthritis, the most common forms of arthritis, are chronic,
painful, and disabling conditions. Although both diseases differ in etiology, they manifest in …

Inflammatory cytokines released from the facet joint tissue in degenerative lumbar spinal disorders

A Igarashi, S Kikuchi, S Konno, K Olmarker - Spine, 2004 - journals.lww.com
Study Design. A prospective study of surgical cases of degenerative lumbar spinal disorders
demonstrated inflammatory cytokines in the facet joint tissue. Objective. To quantify various …

[HTML][HTML] The normal human chondro-osseous junctional region: evidence for contact of uncalcified cartilage with subchondral bone and marrow spaces

TJ Lyons, SF McClure, RW Stoddart… - BMC musculoskeletal …, 2006 - Springer
Background The chondro-osseous junctional region of diarthrodial joints is peculiarly
complex and may be considered to consist of the deepest layer of non-calcified cartilage, the …

The organisation of collagen fibrils in the superficial zones of articular cartilage.

JM Clark - Journal of anatomy, 1990 - ncbi.nlm.nih.gov
The origin and structure of collagen fibres in the surface of articular cartilage were studied
using SEM. Cryofracture was used to create orthogonal fracture surfaces in three planes …

The tidemark of the chondro-osseous junction of the normal human knee joint

TJ Lyons, RW Stoddart, SF McClure… - Journal of molecular …, 2005 - Springer
The chondro-osseous junction includes the junction between calcified and non-calcified
cartilage matrices often referred to as the tidemark. A detailed knowledge of the structure …

[HTML][HTML] Cationic agent contrast-enhanced computed tomography imaging of cartilage correlates with the compressive modulus and coefficient of friction

BA Lakin, DJ Grasso, SS Shah, RC Stewart… - Osteoarthritis and …, 2013 - Elsevier
OBJECTIVE: The aim of this study is to evaluate whether contrast-enhanced computed
tomography (CECT) attenuation, using a cationic contrast agent (CA4+), correlates with the …

The nature and causes of osteoarthrosis.

DL Gardner - British medical journal (Clinical research ed.), 1983 - ncbi.nlm.nih.gov
The term osteoarthrosis describes the condition which may succeed damage to the
avascular, aneural hyaline cartilage of synovial joints. Some authors continue to use the …

Bone density and local growth factors in generalized osteoarthritis

J Dequeker, L Mokassa, J Aerssens… - Microscopy research …, 1997 - Wiley Online Library
Osteoarthritis is usually considered to be a primary disorder of chondrocyte function with
secondary changes in bones. However, a defect in the subchondral bone resulting in loss of …

Assessing cartilage biomechanical properties: techniques for evaluating the functional performance of cartilage in health and disease

BA Lakin, BD Snyder… - Annual review of …, 2017 - annualreviews.org
Osteoarthritis (OA) affects millions of people and results in weakened hyaline cartilage due
to overloading. During joint articulation, hyaline cartilage must withstand high loads while …