An abundance of evidence shows supporting roles for tetraspanin proteins in human cancer.
Many studies show that the expression of tetraspanins correlates with tumour stage, tumour …

One of the hallmarks of cancer is the ability to activate invasion and metastasis. Cancer
morbidity and mortality are largely related to the spread of the primary, localized tumour to …

In pancreatic ductal adenocarcinoma (PDAC), signaling from stromal cells is implicated in
metastatic progression. Tumor-stroma cross-talk is often mediated through extracellular …

CD9 is a crucial regulator of cell adhesion in the immune system and plays important
physiological roles in hematopoiesis, blood coagulation or viral and bacterial infections. It is …

Transmembrane proteins of the tetraspanin superfamily are implicated in a broad spectrum
of cellular processes in many biological systems in both health and disease. Tetraspanins …

Transmembrane protein tetraspanins either promote or suppress tumor invasion and
metastasis. Their effects on tumor progression depend on the multimolecular …

Tetraspanin 8 (TSPAN8) is a member of the tetraspanin superfamily that forms TSPAN8-
mediated protein complexes by interacting with themselves and other various cellular …

Although laparoscopic total gastrectomy (LTG) compared to open total gastrectomy (OTG)
has been widely used for advanced gastric cancer patients, its oncologic validity is yet to be …

Background: Cluster of differentiation molecules are markers of immune cells that have been
identified as a potential immunotherapeutic target for cancer treatment. MicroRNAs are small …

Highlights•Tetraspanins are expressed in solid tumors and hematologic malignancies.•
Tetraspanin 3 has a critical role in myeloid leukemia.•Tetraspanin 3 is a potential target of …