An atlas of genetic determinants of forearm fracture
M Nethander, S Movérare-Skrtic, A Kämpe, E Coward… - Nature Genetics, 2023 - nature.com
Osteoporotic fracture is among the most common and costly of diseases. While reasonably
heritable, its genetic determinants have remained elusive. Forearm fractures are the most …
heritable, its genetic determinants have remained elusive. Forearm fractures are the most …
The role of the endogenous neurotransmitters associated with neuropathic pain and in the opioid crisis: The innate pain-relieving system
Neuropathic pain is a chronic pain caused by central and peripheral nerve injury, long-term
diabetes or treatment with chemotherapy drugs, and it is dissimilar to other chronic pain …
diabetes or treatment with chemotherapy drugs, and it is dissimilar to other chronic pain …
A compendium of validated pain genes
E Wistrom, R Chase, PR Smith… - WIREs Mechanisms of …, 2022 - Wiley Online Library
The development of novel pain therapeutics hinges on the identification and rigorous
validation of potential targets. Model organisms provide a means to test the involvement of …
validation of potential targets. Model organisms provide a means to test the involvement of …
Novel drug-like somatostatin receptor 4 agonists are potential analgesics for neuropathic pain
Somatostatin released from the capsaicin-sensitive sensory nerves mediates analgesic and
anti-inflammatory effects via the somatostatin sst4 receptor without endocrine actions …
anti-inflammatory effects via the somatostatin sst4 receptor without endocrine actions …
Aged females unilaterally hypersensitize, lack descending inhibition, and overexpress alpha1D adrenergic receptors in a murine posttraumatic chronic pain model
SJ Hirsch, A Budig, S Husam, F Birklein - Pain, 2024 - journals.lww.com
Vulnerability to chronic pain is found to depend on age and sex. Most patients with chronic
pain are elderly women, especially with posttraumatic pain after bone fracture that prevails …
pain are elderly women, especially with posttraumatic pain after bone fracture that prevails …
The Genetic Diversity of Stallions of Different Breeds in Russia
N Dementieva, E Nikitkina, Y Shcherbakov… - Genes, 2023 - mdpi.com
The specifics of breeding and selection significantly affect genetic diversity and variability
within a breed. We present the data obtained from the genetic analysis of 21 thoroughbred …
within a breed. We present the data obtained from the genetic analysis of 21 thoroughbred …
Dimethyl trisulfide diminishes traumatic neuropathic pain acting on TRPA1 receptors in mice
Pharmacotherapy of neuropathic pain is still challenging. Our earlier work indicated an
analgesic effect of dimethyl trisulfide (DMTS), which was mediated by somatostatin released …
analgesic effect of dimethyl trisulfide (DMTS), which was mediated by somatostatin released …
Hemokinin-1 gene expression is upregulated in trigeminal ganglia in an inflammatory orofacial pain model: potential role in peripheral sensitization
A large percentage of primary sensory neurons in the trigeminal ganglia (TG) contain
neuropeptides such as tachykinins or calcitonin gene-related peptide. Neuropeptides …
neuropeptides such as tachykinins or calcitonin gene-related peptide. Neuropeptides …
Hemokinin-1 is a mediator of chronic restraint stress-induced pain
The Tac4 gene-derived hemokinin-1 (HK-1) binds to the NK1 receptor, similarly to
Substance P, and plays a role in acute stress reactions and pain transmission in mice. Here …
Substance P, and plays a role in acute stress reactions and pain transmission in mice. Here …
[HTML][HTML] Anti-nociceptive effects of dual neuropeptide antagonist therapy in mouse model of neuropathic and inflammatory pain
MS Kim, BY Kim, A Saghetlians… - The Korean Journal …, 2022 - synapse.koreamed.org
Background Neurokinin-1 (NK1) and calcitonin gene-related peptide (CGRP) play a vital
role in pain pathogenesis, and these proteins' antagonists have attracted attention as …
role in pain pathogenesis, and these proteins' antagonists have attracted attention as …