[HTML][HTML] Superantigen recognition and interactions: functions, mechanisms and applications
AM Deacy, SKE Gan, JP Derrick - Frontiers in Immunology, 2021 - frontiersin.org
Superantigens are unconventional antigens which recognise immune receptors outside
their usual recognition sites eg complementary determining regions (CDRs), to elicit a …
their usual recognition sites eg complementary determining regions (CDRs), to elicit a …
[HTML][HTML] Myeloid antigen-presenting cell niches sustain antitumor T cells and license PD-1 blockade via CD28 costimulation
The mechanisms regulating exhaustion of tumor-infiltrating lymphocytes (TIL) and
responsiveness to PD-1 blockade remain partly unknown. In human ovarian cancer, we …
responsiveness to PD-1 blockade remain partly unknown. In human ovarian cancer, we …
[HTML][HTML] SARS-CoV-2 spike does not possess intrinsic superantigen-like inflammatory activity
C Amormino, V Tedeschi, G Paldino, S Arcieri… - Cells, 2022 - mdpi.com
Multisystem inflammatory syndrome in children (MIS-C) is a rare hyperinflammatory disease
occurring several weeks after SARS-CoV-2 infection. The clinical similarities between MIS-C …
occurring several weeks after SARS-CoV-2 infection. The clinical similarities between MIS-C …
[HTML][HTML] Binding of staphylococcal enterotoxin B (SEB) to B7 receptors triggers TCR-and CD28-mediated inflammatory signals in the absence of MHC class II …
M Kunkl, C Amormino, S Caristi, V Tedeschi… - Frontiers in …, 2021 - frontiersin.org
The inflammatory activity of staphylococcal enterotoxin B (SEB) relies on its capacity to
trigger polyclonal T-cell activation by binding both T-cell receptor (TCR) and costimulatory …
trigger polyclonal T-cell activation by binding both T-cell receptor (TCR) and costimulatory …
Immune checkpoints in sepsis: New hopes and challenges
YC Liu, ST Shou, YF Chai - International Reviews of Immunology, 2022 - Taylor & Francis
Sepsis is a life-threatening syndrome with a high incidence and a weighty economic burden.
The cytokines storm in the early stage and the state of immunosuppression in the late stage …
The cytokines storm in the early stage and the state of immunosuppression in the late stage …
[HTML][HTML] Bivalent binding of staphylococcal superantigens to the TCR and CD28 triggers inflammatory signals independently of antigen presenting cells
M Kunkl, C Amormino, F Spallotta, S Caristi… - Frontiers in …, 2023 - frontiersin.org
Staphylococcus aureu s superantigens (SAgs) such as staphylococcal enterotoxin A (SEA)
and B (SEB) are potent toxins stimulating T cells to produce high levels of inflammatory …
and B (SEB) are potent toxins stimulating T cells to produce high levels of inflammatory …
[HTML][HTML] Targeting staphylococcal enterotoxin B binding to CD28 as a new strategy for dampening superantigen-mediated intestinal epithelial barrier dysfunctions
C Amormino, E Russo, V Tedeschi, MT Fiorillo… - Frontiers in …, 2024 - frontiersin.org
Staphylococcus aureus is a gram-positive bacterium that may cause intestinal inflammation
by secreting enterotoxins, which commonly cause food-poisoning and gastrointestinal …
by secreting enterotoxins, which commonly cause food-poisoning and gastrointestinal …
[HTML][HTML] “small” intestinal Immunopathology plays a “big” role in lethal cytokine release syndrome, and its modulation by interferon-Γ, IL-17A, and a Janus kinase …
SD Kale, BN Mehrkens, MM Stegman… - Frontiers in …, 2020 - frontiersin.org
Chimeric antigen receptor T cell (CART) therapy, administration of certain T cell-agonistic
antibodies, immune check point inhibitors, coronavirus disease 2019 (COVID-19) caused by …
antibodies, immune check point inhibitors, coronavirus disease 2019 (COVID-19) caused by …
CD8+ T cells are necessary for improved sepsis survival induced by CD28 agonism in immunologically experienced mice
JC Anyalebechi, Y Sun, C Davis, ME Wagener… - Frontiers in …, 2024 - frontiersin.org
Introduction A hallmark of T cell dysregulation during sepsis is the downregulation of
costimulatory molecules. CD28 is one of T cell costimulatory molecules significantly altered …
costimulatory molecules. CD28 is one of T cell costimulatory molecules significantly altered …
A highly neutralizing human monoclonal antibody targeting a novel linear epitope on staphylococcal enterotoxin B
H Fan, L Zhao, W Wang, F Yu, H Jing… - Human Vaccines & …, 2024 - Taylor & Francis
ABSTRACT Staphylococcal Enterotoxin B (SEB), produced by Staphylococcus aureus (S.
aureus), is a powerful superantigen that induces severe immune disruption and toxic shock …
aureus), is a powerful superantigen that induces severe immune disruption and toxic shock …