This article continues the series of Surveys and Summaries on restriction endonucleases
(REases) begun this year in Nucleic Acids Research. Here we discuss 'Type II'REases, the …

Naturally occurring modification of the canonical A, G, C, and T bases can be found in the
DNA of cellular organisms and viruses from all domains of life. Bacterial viruses …

The nuclear lamina (NL) interacts with hundreds of large genomic regions termed lamina
associated domains (LADs). The dynamics of these interactions and the relation to …

Chemical modifications to nucleic acids occur across the kingdoms of life and carry
important regulatory information. Reliable high-resolution mapping of these modifications is …

The 1952 observation of host-induced non-hereditary variation in bacteriophages by
Salvador Luria and Mary Human led to the discovery in the 1960s of modifying enzymes that …

Bacteriophages or phages are viruses that infect bacterial cells (for the scope of this review
we will also consider viruses that infect Archaea). Constant threat of phage infection is a …

Although extensively studied in prokaryotes, the prevalence and significance of DNA N 6-
methyladenine (6mA or m6dA) in eukaryotes had been underappreciated until recent …

Abstract DNA N6-methyladenine (6 mA) is a new type of DNA methylation identified in
various eukaryotic cells. However, its alteration and genomic distribution features in …

The winged helix domain (WHD) is a widespread nucleic-acid-binding protein structural
element found in all kingdoms of life. Although the overall structure of the WHD is conserved …

Chemical modifications to DNA and histone proteins are involved in epigenetic programs
underlying cellular differentiation and development. Regulatory networks involving …