Some naturally occurring compounds that increase longevity and stress resistance in model organisms of aging

DR Gómez-Linton, S Alavez, A Alarcón-Aguilar… - Biogerontology, 2019 - Springer
Humans and other organisms show age-related signs of deterioration, which makes aging
an interesting process to study. In the present work, we review the anti-aging evidence of …

Cancer chemoprevention via activation of proteostatic modules

A Sklirou, ED Papanagnou, N Fokialakis, IP Trougakos - Cancer Letters, 2018 - Elsevier
Proteins carry out the majority of cellular functions and maintain cellular homeodynamics
mostly by participating in multimeric assemblies that operate as protein machines. Proteome …

Targeting protein quality control mechanisms by natural products to promote healthy ageing

S Wedel, M Manola, M Cavinato, IP Trougakos… - Molecules, 2018 - mdpi.com
Organismal ageing is associated with increased chance of morbidity or mortality and it is
driven by diverse molecular pathways that are affected by both environmental and genetic …

Isolation of natural products with anti-ageing activity from the fruits of Platanus orientalis

S Chatzigeorgiou, QD Thai, J Tchoumtchoua, K Tallas… - Phytomedicine, 2017 - Elsevier
Background Ageing is defined as the time-dependent decline of functional capacity and
stress resistance resulting in increased morbidity and mortality. Hypothesis/Purpose …

Regulation of gene expression through food—Curcumin as a sirtuin activity modulator

A Ungurianu, A Zanfirescu, D Margină - Plants, 2022 - mdpi.com
The sirtuin family comprises NAD+-dependent protein lysine deacylases, mammalian
sirtuins being either nuclear (SIRT1, SIRT2, SIRT6, and SIRT7), mitochondrial (SIRT3 …

Comparative analysis of oxidative mechanisms of phloroglucinol and dieckol by electrochemical, spectroscopic, cellular and computational methods

D Zhang, C Wang, L Shen, HC Shin, KB Lee, B Ji - RSC advances, 2018 - pubs.rsc.org
Numerous studies have been carried out on the redox activities of phenolic compounds from
terrestrial plants, however, the redox pathway of phlorotannins, a type of marine algae …

Progressing neurobiological strategies against proteostasis failure: Challenges in neurodegeneration

A Amanullah, A Upadhyay, V Joshi, R Mishra… - Progress in …, 2017 - Elsevier
Proteins are ordered useful cellular entities, required for normal health and organism's
survival. The proteome is the absolute set of cellular expressed proteins, which regulates a …

Potential Antiaging Effects of DLBS1649, a Centella asiatica Bioactive Extract

AH Karsono, OM Tandrasasmita, G Berlian… - Journal of …, 2021 - Taylor & Francis
Purpose Centella asiatica is a traditional medicinal plant, especially for wound healing and
as a neuroprotective agent. DLBS1649 is a bioactive extract from C. asiatica, and was …

The evaluation of pro-cognitive and antiamnestic properties of berberine and magnoflorine isolated from barberry species by centrifugal partition chromatography …

W Kukula-Koch, M Kruk-Słomka, K Stępnik… - International Journal of …, 2017 - mdpi.com
Civilization diseases associated with memory disorders are important health problems
occurring due to a prolonged life span. The manuscript shows the results of an in vivo study …

Medicinal plants: A rich source of bioactive molecules used in drug development

L Rathor - Evidence Based Validation of Traditional Medicines: A …, 2021 - Springer
Medicinal plants are a rich repository of various biologically active molecules that have
various pharmacological effects in mammals. The majority of the world's population (around …