The challenge of applications of probiotics in gastrointestinal diseases

W Wolfe, Z Xiang, X Yu, P Li, H Chen… - Advanced Gut & …, 2023 - Wiley Online Library
Gastrointestinal disease is characterized by gastrointestinal dysfunction with dysbiosis of the
microbiome. Probiotics may act as biological agents in treating gastrointestinal diseases …

CRISPR-Cas-based antimicrobials: design, challenges, and bacterial mechanisms of resistance

A Mayorga-Ramos, J Zúñiga-Miranda… - ACS Infectious …, 2023 - ACS Publications
The emergence of antibiotic-resistant bacterial strains is a source of public health concern
across the globe. As the discovery of new conventional antibiotics has stalled significantly …

Engineered phage with antibacterial CRISPR–Cas selectively reduce E. coli burden in mice

YE Gencay, D Jasinskytė, C Robert, S Semsey… - Nature …, 2024 - nature.com
Antibiotic treatments have detrimental effects on the microbiome and lead to antibiotic
resistance. To develop a phage therapy against a diverse range of clinically relevant …

Intestinal colonization with multidrug-resistant Enterobacterales: screening, epidemiology, clinical impact, and strategies to decolonize carriers

EI Campos-Madueno, M Moradi, Y Eddoubaji… - European Journal of …, 2023 - Springer
The clinical impact of infections due to extended-spectrum β-lactamase (ESBL)-and/or
carbapenemase-producing Enterobacterales (Ent) has reached dramatic levels worldwide …

Microbial applications for sustainable space exploration beyond low Earth orbit

AP Koehle, SL Brumwell, EP Seto, AM Lynch… - npj …, 2023 - nature.com
With the construction of the International Space Station, humans have been continuously
living and working in space for 22 years. Microbial studies in space and other extreme …

Targeted bacterial conjugation mediated by synthetic cell-to-cell adhesions

M Robledo, B Álvarez, A Cuevas… - Nucleic Acids …, 2022 - academic.oup.com
Genetic interventions on microbiomes, for clinical or biotechnological purposes, remain
challenging. Conjugation-based delivery of genetic cargo is still unspecific and limited by …

Engineering Escherichia coli Nissle 1917 as a microbial chassis for therapeutic and industrial applications

M Yu, S Hu, B Tang, H Yang, D Sun - Biotechnology Advances, 2023 - Elsevier
Genetically engineered microbes, especially Escherichia coli, have been widely used in the
biosynthesis of proteins and metabolites for medical and industrial applications. As a …

Computational design of CRISPR guide RNAs to enable strain-specific control of microbial consortia

AG Rottinghaus, S Vo, TS Moon - Proceedings of the …, 2023 - National Acad Sciences
Microbes naturally coexist in complex, multistrain communities. However, extracting
individual microbes from and specifically manipulating the composition of these consortia …

Fecal microbiota transplantation and other gut microbiota manipulation strategies

G Quaranta, A Guarnaccia, G Fancello, C Agrillo… - Microorganisms, 2022 - mdpi.com
The gut microbiota is composed of bacteria, archaea, phages, and protozoa. It is now well
known that their mutual interactions and metabolism influence host organism …

[HTML][HTML] Microbiome-liver crosstalk: A multihit therapeutic target for liver disease

J Kirundi, S Moghadamrad… - World journal of …, 2023 - ncbi.nlm.nih.gov
Liver disease has become a leading cause of death, particularly in the West, where it is
attributed to more than two million deaths annually. The correlation between gut microbiota …