The challenge of applications of probiotics in gastrointestinal diseases
Gastrointestinal disease is characterized by gastrointestinal dysfunction with dysbiosis of the
microbiome. Probiotics may act as biological agents in treating gastrointestinal diseases …
microbiome. Probiotics may act as biological agents in treating gastrointestinal diseases …
CRISPR-Cas-based antimicrobials: design, challenges, and bacterial mechanisms of resistance
A Mayorga-Ramos, J Zúñiga-Miranda… - ACS Infectious …, 2023 - ACS Publications
The emergence of antibiotic-resistant bacterial strains is a source of public health concern
across the globe. As the discovery of new conventional antibiotics has stalled significantly …
across the globe. As the discovery of new conventional antibiotics has stalled significantly …
Engineered phage with antibacterial CRISPR–Cas selectively reduce E. coli burden in mice
Antibiotic treatments have detrimental effects on the microbiome and lead to antibiotic
resistance. To develop a phage therapy against a diverse range of clinically relevant …
resistance. To develop a phage therapy against a diverse range of clinically relevant …
Intestinal colonization with multidrug-resistant Enterobacterales: screening, epidemiology, clinical impact, and strategies to decolonize carriers
EI Campos-Madueno, M Moradi, Y Eddoubaji… - European Journal of …, 2023 - Springer
The clinical impact of infections due to extended-spectrum β-lactamase (ESBL)-and/or
carbapenemase-producing Enterobacterales (Ent) has reached dramatic levels worldwide …
carbapenemase-producing Enterobacterales (Ent) has reached dramatic levels worldwide …
Microbial applications for sustainable space exploration beyond low Earth orbit
AP Koehle, SL Brumwell, EP Seto, AM Lynch… - npj …, 2023 - nature.com
With the construction of the International Space Station, humans have been continuously
living and working in space for 22 years. Microbial studies in space and other extreme …
living and working in space for 22 years. Microbial studies in space and other extreme …
Targeted bacterial conjugation mediated by synthetic cell-to-cell adhesions
M Robledo, B Álvarez, A Cuevas… - Nucleic Acids …, 2022 - academic.oup.com
Genetic interventions on microbiomes, for clinical or biotechnological purposes, remain
challenging. Conjugation-based delivery of genetic cargo is still unspecific and limited by …
challenging. Conjugation-based delivery of genetic cargo is still unspecific and limited by …
Engineering Escherichia coli Nissle 1917 as a microbial chassis for therapeutic and industrial applications
Genetically engineered microbes, especially Escherichia coli, have been widely used in the
biosynthesis of proteins and metabolites for medical and industrial applications. As a …
biosynthesis of proteins and metabolites for medical and industrial applications. As a …
Computational design of CRISPR guide RNAs to enable strain-specific control of microbial consortia
AG Rottinghaus, S Vo, TS Moon - Proceedings of the …, 2023 - National Acad Sciences
Microbes naturally coexist in complex, multistrain communities. However, extracting
individual microbes from and specifically manipulating the composition of these consortia …
individual microbes from and specifically manipulating the composition of these consortia …
Fecal microbiota transplantation and other gut microbiota manipulation strategies
G Quaranta, A Guarnaccia, G Fancello, C Agrillo… - Microorganisms, 2022 - mdpi.com
The gut microbiota is composed of bacteria, archaea, phages, and protozoa. It is now well
known that their mutual interactions and metabolism influence host organism …
known that their mutual interactions and metabolism influence host organism …
[HTML][HTML] Microbiome-liver crosstalk: A multihit therapeutic target for liver disease
J Kirundi, S Moghadamrad… - World journal of …, 2023 - ncbi.nlm.nih.gov
Liver disease has become a leading cause of death, particularly in the West, where it is
attributed to more than two million deaths annually. The correlation between gut microbiota …
attributed to more than two million deaths annually. The correlation between gut microbiota …