Actin-based protrusions are at the base of many fundamental cellular processes, such as
cell adhesion, migration and intercellular communication. In recent decades, the discovery …

Confined cells migrating through 3D environments are also constrained by the laws of
physics, meaning for every action there must be an equal and opposite reaction for cells to …

Mechanical force generation plays an essential role in many cellular functions, including
mitosis. Actomyosin contractile forces mediate changes in cell shape in mitosis and are …

Various heterozygous cytoskeletal γ-actin mutations have been shown to cause Baraitser–
Winter cerebrofrontofacial syndrome, non-syndromic hearing loss, or isolated eye coloboma …

Focal adhesions (FAs) connect inner workings of cell to the extracellular matrix to control cell
adhesion, migration and mechanosensing. Previous studies demonstrated that FAs contain …

Apical extrusion is a tissue-intrinsic process that allows epithelia to eliminate unfit or surplus
cells. This is exemplified by the early extrusion of apoptotic cells, which is critical to maintain …

Force generation and motility by actomyosin in non-muscle cells are spatially regulated by∼
40 tropomyosin (Tpm) isoforms. The means by which Tpms are targeted to specific cellular …

Myosin 5c (Myo5c) is a motor protein that is produced in epithelial and glandular tissues,
where it plays an important role in secretory processes. Myo5c is composed of two heavy …

Members of the myosin superfamily of molecular motors are large mechanochemical
ATPases that are implicated in an ever-expanding array of cellular functions. This review …

Apical extrusion is a tissue-intrinsic process that allows epithelia to eliminate unfit or surplus
cells. This is exemplified by the early extrusion of apoptotic cells, which is critical to maintain …