Developments and challenges for new and emergent preparations for male hypogonadism treatment

G Corona, C Sparano, G Rastrelli… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction The specific role of testosterone (T) replacement therapy in patients with late
onset hypogonadism is still conflicting. Several available preparations have been developed …

Selective androgen receptor modulator use and related adverse events including drug-induced liver injury: analysis of suspected cases

N Leciejewska, K Jędrejko, VM Gómez-Renaud… - European Journal of …, 2024 - Springer
Purpose Selective androgen receptor modulators (SARMs) have demonstrated agonist
activity on the androgen receptor in various tissues, stimulating muscle mass growth and …

[HTML][HTML] Sex-specific cytotoxicity of ostarine in cardiomyocytes

N Leciejewska, E Pruszyńska–Oszmałek… - Molecular and Cellular …, 2023 - Elsevier
Ostarine is the most popular compound in the selective androgen receptor modulator group
(SARMs). Ostarine is used as a physical performance-enhancing agent. The abuse of this …

Adjuvant pharmacological strategies for the musculoskeletal system during long‐term space missions

F Thomasius, D Pesta… - British Journal of Clinical …, 2023 - Wiley Online Library
Despite 2 h of daily exercise training, muscle wasting and bone loss are still present after 6‐
month missions to the international space station. Some crew members lose bone much …

Liver Injury after Selective Androgen Receptor Modulator Intake: A Case Report and Review of the Literature

JE Mertens, MTC Bömmer, MB Regier… - Zeitschrift für …, 2023 - thieme-connect.com
Liver injury associated with selective androgen receptor modulators (SARMs) is an issue
that has not been reported often. We report a case of a previously healthy 24-year-old male …

Effects of ostarine and endurance training on some functional, hematological, and biochemical parameters in male rats

V Vasilev, N Boaydjiev, T Deneva… - Asian Journal of …, 2024 - brieflands.com
Background: Non-steroidal Selective Androgen Receptor Modulators (SARMs) are currently
a group of drug candidates with anabolic effects, tissue selectivity, and the potential to …

[HTML][HTML] Bile cast nephropathy because of acute liver injury associated with selective androgen receptor modulators

C Arayangkool, M Gozun, M Tanariyakul… - ACG Case Reports …, 2023 - journals.lww.com
Selective androgen receptor modulators (SARMs) are novel nonsteroidal agents abused for
performance enhancement such as anabolic steroids. We report a case of a 27-year-old …

Advances in SARMs anti‐doping analysis

K Slíž, P Mikuš - Drug Testing and Analysis, 2024 - Wiley Online Library
Selective androgen receptor modulators (SARMs) are performance‐enhancing drugs
(PEDs) that stimulate anabolism, increase muscle mass and strength and promote recovery …

Hepatotoxicity due to dietary supplements: state-of-the-art, gaps and perspectives

F Rivero-Pino, AG Casanova - Critical Reviews in Toxicology, 2023 - Taylor & Francis
Food supplements are products intended to complement the normal diet and consist of
concentrated sources of nutrients or other substances with a nutritional or physiological …

[引用][C] Muscles at the expense of liver injury. Is it worth it?

C Stephens - Alimentary Pharmacology & Therapeutics, 2024 - Wiley Online Library
LINKED CONTENT This article is linked to Nash et al paper. To view this article, visit
https://doi. org/10.1111/apt. 17906