Development, circuitry, and function of the zebrafish cerebellum

S Pose-Méndez, P Schramm, K Valishetti… - Cellular and Molecular …, 2023 - Springer
The cerebellum represents a brain compartment that first appeared in gnathostomes (jawed
vertebrates). Besides the addition of cell numbers, its development, cytoarchitecture …

Evolutionary mechanisms that generate morphology and neural‐circuit diversity of the cerebellum

M Hibi, K Matsuda, M Takeuchi… - Development …, 2017 - Wiley Online Library
The cerebellum is derived from the dorsal part of the anterior‐most hindbrain. The vertebrate
cerebellum contains glutamatergic granule cells (GCs) and gamma‐aminobutyric acid …

Single-cell lineage tracing by integrating CRISPR-Cas9 mutations with transcriptomic data

H Zafar, C Lin, Z Bar-Joseph - Nature communications, 2020 - nature.com
Recent studies combine two novel technologies, single-cell RNA-sequencing and CRISPR-
Cas9 barcode editing for elucidating developmental lineages at the whole organism level …

Motor context dominates output from purkinje cell functional regions during reflexive visuomotor behaviours

LD Knogler, AM Kist, R Portugues - Elife, 2019 - elifesciences.org
The cerebellum integrates sensory stimuli and motor actions to enable smooth coordination
and motor learning. Here we harness the innate behavioral repertoire of the larval zebrafish …

GATA4/5/6 family transcription factors are conserved determinants of cardiac versus pharyngeal mesoderm fate

M Song, X Yuan, C Racioppi, M Leslie, N Stutt… - Science …, 2022 - science.org
GATA4/5/6 transcription factors play essential, conserved roles in heart development. To
understand how GATA4/5/6 modulates the mesoderm-to-cardiac fate transition, we labeled …

Distinct responses of Purkinje neurons and roles of simple spikes during associative motor learning in larval zebrafish

TC Harmon, U Magaram, DL McLean, IM Raman - Elife, 2017 - elifesciences.org
To study cerebellar activity during learning, we made whole-cell recordings from larval
zebrafish Purkinje cells while monitoring fictive swimming during associative conditioning …

Toxicity assessment of hexafluoropropylene oxide-dimer acid on morphology, heart physiology, and gene expression during zebrafish (Danio rerio) development

S Gong, F McLamb, D Shea, JP Vu… - … Science and Pollution …, 2023 - Springer
Hexafluoropropylene oxide-dimer acid (HFPO-DA) is one of the emerging replacements for
the “forever” carcinogenic and toxic long-chain PFAS. HFPO-DA is a polymerization aid …

Modeling neurodegenerative spinocerebellar ataxia type 13 in zebrafish using a Purkinje neuron specific tunable coexpression system

K Namikawa, A Dorigo, M Zagrebelsky… - Journal of …, 2019 - Soc Neuroscience
Purkinje cells (PCs) are primarily affected in neurodegenerative spinocerebellar ataxias
(SCAs). For generating animal models for SCAs, genetic regulatory elements specifically …

Tracing of afferent connections in the zebrafish cerebellum using recombinant rabies virus

R Dohaku, M Yamaguchi, N Yamamoto… - Frontiers in neural …, 2019 - frontiersin.org
The cerebellum is involved in some forms of motor coordination and learning, and in
cognitive and emotional functions. To elucidate the functions of the cerebellum, it is …

The Opsin 3/Teleost multiple tissue opsin system: mRNA localization in the retina and brain of medaka (Oryzias latipes)

K Sato, H Ohuchi - Journal of Comparative Neurology, 2021 - Wiley Online Library
The photoreceptor protein, opsin, is one of the major components for vision and
photoreceptive function in animals. Although many opsins have been discovered from …