MTGO: PPI network analysis via topological and functional module identification

D Vella, S Marini, F Vitali, D Di Silvestre, G Mauri… - Scientific reports, 2018 - nature.com
Protein-protein interaction (PPI) networks are viable tools to understand cell functions,
disease machinery, and drug design/repositioning. Interpreting a PPI, however, it is a …

Immune profiling of plasma-derived extracellular vesicles identifies Parkinson disease

E Vacchi, J Burrello, D Di Silvestre… - Neurology …, 2020 - AAN Enterprises
Objective To develop a diagnostic model based on plasma-derived extracellular vesicle
(EV) subpopulations in Parkinson disease (PD) and atypical parkinsonism (AP), we applied …

[HTML][HTML] Plasma exosomes characterization reveals a perioperative protein signature in older patients undergoing different types of on-pump cardiac surgery

A Carrozzo, V Casieri, D Di Silvestre, F Brambilla… - Geroscience, 2021 - Springer
Although exosomes are extracellular nanovesicles mainly involved in cardioprotection, it is
not known whether plasma exosomes of older patients undergoing different types of on …

The Protein Network in Subcutaneous Fat Biopsies from Patients with AL Amyloidosis: More Than Diagnosis?

D Di Silvestre, F Brambilla, F Lavatelli, M Chirivì… - Cells, 2023 - mdpi.com
AL amyloidosis is caused by the misfolding of immunoglobulin light chains leading to an
impaired function of tissues and organs in which they accumulate. Due to the paucity of …

Proteome investigation of rat lungs subjected to Ex vivo perfusion (EVLP)

V Roffia, A De Palma, C Lonati, D Di Silvestre, R Rossi… - Molecules, 2018 - mdpi.com
Ex vivo lung perfusion (EVLP) is an emerging procedure that allows organ preservation,
assessment and reconditioning, increasing the number of marginal donor lungs for …

The effects of hypoxic preconditioned murine mesenchymal stem cells on post-infarct arrhythmias in the mouse model

B Ahmad, A Skorska, M Wolfien, H Sadraddin… - International Journal of …, 2022 - mdpi.com
Ventricular arrhythmias associated with myocardial infarction (MI) have a significant impact
on mortality in patients following heart attack. Therefore, targeted reduction of arrhythmia …

An integrative methodology based on protein-protein interaction networks for identification and functional annotation of disease-relevant genes applied to …

M Marín, FJ Esteban, H Ramírez-Rodrigo, E Ros… - BMC …, 2019 - Springer
Background Biologically data-driven networks have become powerful analytical tools that
handle massive, heterogeneous datasets generated from biomedical fields. Protein-protein …

Micro-biopsy for detection of gene expression changes in ischemic swine myocardium: A pilot study

A Chireh, R Grankvist, M Sandell, AK Mukarram… - Plos one, 2021 - journals.plos.org
Micro-endomyocardial biopsy (micro-EMB) is a novel catheter-based biopsy technique,
aiming to increase flexibility and safety compared to conventional EMB. The technique was …

Analysing omics data sets with weighted nodes networks (WNNets)

G Tosadori, D Di Silvestre, F Spoto, P Mauri… - Scientific Reports, 2021 - nature.com
Current trends in biomedical research indicate data integration as a fundamental step
towards precision medicine. In this context, network models allow representing and …

Estudio del Impacto de la Dinámica Neuronal en el Procesamiento de Información en la Capa Granular del Cerebelo

M Marín Alejo - 2021 - digibug.ugr.es
The cerebellum is a critical brain area for sensorimotor and also non-motor functions such
as cognitive and emotional processes. Cerebellar lesions contribute to pathological …