Impact of host immunity on HTLV-1 pathogenesis: potential of Tax-targeted immunotherapy against ATL

M Kannagi, A Hasegawa, Y Nagano, S Kimpara… - Retrovirology, 2019 - Springer
Human T-cell leukemia virus type-1 (HTLV-1) causes adult T-cell leukemia/lymphoma (ATL),
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), and other …

[HTML][HTML] Interplay between innate immunity and the viral oncoproteins Tax and HBZ in the pathogenesis and therapeutic response of HTLV-1 associated adult T cell …

H El Hajj, A Bazarbachi - Frontiers in Immunology, 2022 - frontiersin.org
The Human T-cell Leukemia virus type 1 (HTLV-1) causes an array of pathologies, the most
aggressive of which is adult T-cell leukemia (ATL), a fatal blood malignancy with dismal …

HTLV-1 extracellular vesicles promote cell-to-cell contact

DO Pinto, C DeMarino, ML Pleet, M Cowen… - Frontiers in …, 2019 - frontiersin.org
Human T-cell leukemia virus-1 (HTLV-1) is a neglected and incurable retrovirus estimated to
infect 5 to 10 million worldwide. Specific indigenous Australian populations report infection …

The HTLV-1 viral oncoproteins Tax and HBZ reprogram the cellular mRNA splicing landscape

C Vandermeulen, T O'grady, J Wayet, B Galvan… - PLoS …, 2021 - journals.plos.org
Viral infections are known to hijack the transcription and translation of the host cell.
However, the extent to which viral proteins coordinate these perturbations remains unclear …

Virus, exosome, and MicroRNA: new insights into autophagy

J Sadri Nahand, A Salmaninejad, S Mollazadeh… - Cell Biology and …, 2022 - Springer
Autophagy is known as a conserved self-eating mechanism that contributes to cells to
degrade different intracellular components (ie, macromolecular complexes, aggregated …

Adult T-cell leukemia: a comprehensive overview on current and promising treatment modalities

R Hleihel, A Akkouche, H Skayneh, O Hermine… - Current Oncology …, 2021 - Springer
Abstract Purpose of the Review Adult T-cell leukemia (ATL) is an aggressive chemo-
resistant malignancy secondary to HTLV-1 retrovirus. Prognosis of ATL remains dismal …

Bovine leukemia virus relation to human breast cancer: Meta-analysis

A Gao, VL Kouznetsova, IF Tsigelny - Microbial Pathogenesis, 2020 - Elsevier
Bovine leukemia virus (BLV) is a virus that infects cattle around the world and is very similar
to the human T-cell leukemia virus (HTLV), which causes adult T-cell leukemia/lymphoma …

[HTML][HTML] Autophagy in viral development and progression of cancer

A Suares, MV Medina, O Coso - Frontiers in oncology, 2021 - frontiersin.org
Autophagy is a complex degradative process by which eukaryotic cells capture cytoplasmic
components for subsequent degradation through lysosomal hydrolases. Although this …

Origin, evolution and stability of overlapping genes in viruses: a systematic review

A Pavesi - Genes, 2021 - mdpi.com
During their long evolutionary history viruses generated many proteins de novo by a
mechanism called “overprinting”. Overprinting is a process in which critical nucleotide …

[HTML][HTML] Dual cytoplasmic and nuclear localization of HTLV-1-encoded HBZ protein is a unique feature of adult T-cell leukemia

G Forlani, M Shallak, A Tedeschi, I Cavallari… - …, 2021 - ncbi.nlm.nih.gov
Adult T-cell leukemia-lymphoma (ATL), is a highly malignant T-cell neoplasm caused by
human T-cell leukemia virus type 1 (HTLV-1), characterized by poor prognosis. Two viral …