[HTML][HTML] Dual cytoplasmic and nuclear localization of HTLV-1-encoded HBZ protein is a unique feature of adult T-cell leukemia

G Forlani, M Shallak, A Tedeschi, I Cavallari… - …, 2021 - ncbi.nlm.nih.gov
Adult T-cell leukemia-lymphoma (ATL), is a highly malignant T-cell neoplasm caused by
human T-cell leukemia virus type 1 (HTLV-1), characterized by poor prognosis. Two viral …

Aberrant splicing events and epigenetics in viral oncogenomics: Current therapeutic strategies

FZ Francies, Z Dlamini - Cells, 2021 - mdpi.com
Global cancer incidence and mortality are on the rise. Although cancer is fundamentally a
non-communicable disease, a large number of cancers are known to have a viral aetiology …

HTLV‐1 oncovirus‐host interactions: From entry to the manifestation of associated diseases

S Ahmadi Ghezeldasht, SAA Shamsian… - Reviews in medical …, 2021 - Wiley Online Library
Human T lymphotropic virus type‐1 (HTLV‐1) is a well‐known human oncovirus, associated
with two life‐threatening diseases, adult T cell leukaemia/lymphoma (ATL) and HTLV‐1 …

Restriction factors in human retrovirus infections and the unprecedented case of CIITA as link of intrinsic and adaptive immunity against HTLV-1

G Forlani, M Shallak, E Ramia, A Tedeschi, RS Accolla - Retrovirology, 2019 - Springer
Background Immunity against pathogens evolved through complex mechanisms that only for
sake of simplicity are defined as innate immunity and adaptive immunity. Indeed innate and …

HTLV-1 HBZ protein resides exclusively in the cytoplasm of infected cells in asymptomatic carriers and HAM/TSP patients

G Forlani, M Baratella, A Tedeschi, C Pique… - Frontiers in …, 2019 - frontiersin.org
Human T cell lymphotropic virus type 1 (HTLV-1) is the causative agent of adult T cell
leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis …

TRAF3 is required for NF-κB pathway activation mediated by HTLV tax proteins

S Fochi, E Bergamo, M Serena, S Mutascio… - Frontiers in …, 2019 - frontiersin.org
Human T-cell leukemia viruses type 1 (HTLV-1) and type 2 (HTLV-2) share a common
genome organization and expression strategy but have distinct pathological properties …

Creation of the HIV-1 antisense gene asp coincided with the emergence of the pandemic group M and is associated with faster disease progression

A Pavesi, F Romerio - Microbiology Spectrum, 2024 - Am Soc Microbiol
Despite being first identified more than three decades ago, the antisense gene asp of HIV-1
remains an enigma. asp is present uniquely in pandemic (group M) HIV-1 strains, and it is …

Influence of immunogenetic biomarkers in the clinical outcome of HTLV-1 infected persons

ACR Vallinoto, I Cayres-Vallinoto, MA Freitas Queiroz… - Viruses, 2019 - mdpi.com
Human T-lymphotropic virus 1, a member of the Retroviridae family, causes a neglected,
silent, persistent infection affecting circa 5 to 10 million people around the world, with …

Advances in the treatment of human T-cell lymphotropic virus type-I associated myelopathy

B Mashkani, M Jalili Nik, SA Rezaee… - Expert Review of …, 2023 - Taylor & Francis
ABSTRACT Introduction Nearly 2–3% of those 10 to 20 million individuals infected with the
Human T-cell lymphotropic virus type-1 (HTLV-1); are predisposed to developing HTLV-1 …

Hijacking Host Immunity by the Human T-Cell Leukemia Virus Type-1: Implications for Therapeutic and Preventive Vaccines

CA Pise-Masison, G Franchini - Viruses, 2022 - mdpi.com
Human T-cell Leukemia virus type-1 (HTLV-1) causes adult T-cell leukemia/lymphoma
(ATLL), HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and other …