Nonspecific binding—fundamental concepts and consequences for biosensing applications

A Frutiger, A Tanno, S Hwu, RF Tiefenauer… - Chemical …, 2021 - ACS Publications
Nature achieves differentiation of specific and nonspecific binding in molecular interactions
through precise control of biomolecules in space and time. Artificial systems such as …

Human memory T cells: generation, compartmentalization and homeostasis

DL Farber, NA Yudanin, NP Restifo - Nature Reviews Immunology, 2014 - nature.com
Memory T cells constitute the most abundant lymphocyte population in the body for the
majority of a person's lifetime; however, our understanding of memory T cell generation …

CD4+ T cells contribute to neurodegeneration in Lewy body dementia

D Gate, E Tapp, O Leventhal, M Shahid, TJ Nonninger… - Science, 2021 - science.org
Recent studies indicate that the adaptive immune system plays a role in Lewy body
dementia (LBD). However, the mechanism regulating T cell brain homing in LBD is …

Regulation of immune responses by prostaglandin E2

P Kalinski - The Journal of Immunology, 2012 - journals.aai.org
PGE 2, an essential homeostatic factor, is also a key mediator of immunopathology in
chronic infections and cancer. The impact of PGE 2 reflects the balance between its …

Foreign body reaction to biomaterials

JM Anderson, A Rodriguez, DT Chang - Seminars in immunology, 2008 - Elsevier
The foreign body reaction composed of macrophages and foreign body giant cells is the end-
stage response of the inflammatory and wound healing responses following implantation of …

Phenotypical and functional specialization of FOXP3+ regulatory T cells

DJ Campbell, MA Koch - Nature Reviews Immunology, 2011 - nature.com
Abstract Forkhead box P3 (FOXP3)+ regulatory T (TReg) cells prevent autoimmune disease,
maintain immune homeostasis and modulate immune responses during infection. To …

The many roles of chemokines and chemokine receptors in inflammation

IF Charo, RM Ransohoff - New England Journal of Medicine, 2006 - Mass Medical Soc
The Many Roles of Chemokines and Chemokine Receptors in Inflammation | New England
Journal of Medicine Skip to main content The New England Journal of Medicine homepage …

The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes

K Balabanian, B Lagane, S Infantino, KYC Chow… - Journal of Biological …, 2005 - ASBMB
Combined phylogenetic and chromosomal location studies suggest that the orphan receptor
RDC1 is related to CXC chemokine receptors. RDC1 provides a co-receptor function for a …

Immunity, inflammation, and allergy in the gut

TT MacDonald, G Monteleone - Science, 2005 - science.org
The gut immune system has the challenge of responding to pathogens while remaining
relatively unresponsive to food antigens and the commensal microflora. In the developed …

Human bone marrow stromal cells express a distinct set of biologically functional chemokine receptors

M Honczarenko, YI Le, M Swierkowski, I Ghiran… - Stem …, 2006 - academic.oup.com
Stromal cells isolated from bone marrow (BMSCs), often referred to as mesenchymal stem
cells, are currently under investigation for a variety of therapeutic applications. However …