Simple Summary Breast cancer (BC) is the most frequent malignancy diagnosed in 2020
worldwide. Despite significant advances in BC therapy, its pathogenesis is still not fully …

Genetic aberration including mutation in oncogenes and tumor suppressor genes transforms
normal cells into tumor cells. Epigenetic modifications work concertedly with genetic factors …

Beyond its use as an antiepileptic drug, over time valproate has been increasingly used for
several other therapeutic applications. Among these, the antineoplastic effects of valproate …

The high frequency of breast cancer worldwide and the high mortality among women with
this malignancy are a serious challenge for modern medicine. A deeper understanding of …

Breast cancer remains a common cause of cancer-related death in women. Therefore,
further studies are necessary for the comprehension of breast cancer and the revolution of …

Histone deacetylases (HDAC) are enzymes that play a role in chromatin remodeling and
epigenetics. They belong to a specific category of enzymes that eliminate the acetyl part of …

Breast cancer is the leading cause of death among women worldwide, and certain subtypes
are highly aggressive and drug resistant. As oxidative stress is linked to the onset and …

Background Breast cancer is the second leading cause of death among women after lung
cancer. Despite the improvement in prevention and in therapy, breast cancer still remains a …

Breast carcinoma (BC) is the most commonly diagnosed type of cancer in women in the
world. Although the advances in the treatment of BC patients are significant, numerous side …

Cisplatin is an effective chemotherapeutic agent for treating triple negative breast cancer
(TNBC). Nevertheless, cisplatin-resistance might develop during the course of treatment …