Chemotherapy is the first choice in the treatment of cancer and is always preferred to other
approaches such as radiation and surgery, but it has never met the need of patients for a …

Carbosilane dendrimers are a particular type of dendrimer structure that has been used as
delivery vehicles for drugs and nucleic acids. They have a defined structure according to …

To improve the efficacy of nucleic acid-based therapeutics, eg, small interfering RNA
(siRNA), transfection agents are needed for efficient delivery into cells. Several classes of …

Drug delivery to the central nervous system is restricted by the blood-brain barrier (BBB).
However, with the onset of stroke, the BBB becomes leaky, providing a window of …

The disruption of the cellular pathways of protein biosynthesis through the mechanism of
RNA interference has been recognized as a tool of great diagnostic and therapeutic …

The transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2) is considered as the
master regulator of antioxidant and cytoprotective gene expressions. Moreover, it plays a …

Over the past 60 years of development, biomaterials have demonstrated outstanding
versatility to ensure controlled, reproducible drug delivery. These drug delivery systems …

Dendrimers, which are considered as one of the most promising tools in the field of
nanobiotechnology due to their structural organization, showed a great potential in gene …

Numerous therapeutic and diagnostic approaches used within a clinical setting depend on
the administration of compounds via systemic delivery. Biomaterials at the nanometer scale …

The repeated administration of non-degradable dendrimers can lead to toxicity due to their
bioaccumulation. Furthermore, in drug delivery applications, carrier stability can result in low …