Transdermal drug delivery has made an important contribution to medical practice, but has
yet to fully achieve its potential as an alternative to oral delivery and hypodermic injections …

Protein kinase inhibitors are a well-established class of clinically useful drugs, particularly
for the treatment of cancer. Achieving inhibitor selectivity for particular protein kinases often …

Among the ten pharmacological inhibitors of cyclin-dependent kinases (CDKs) currently in
clinical trials, the purine roscovitine (CYC202, Seliciclib) is undergoing phase 2 trials against …

Managing diabetes that is a global life-threatening problem, remains a challenge for the
scientific community. The inhibition of α-amylase and α-glucosidase enzymes which are …

Cyclin-dependent kinases (CDKs) and casein kinases 1 (CK1) are involved in the two key
molecular features of Alzheimer's disease, production of amyloid-β peptides (extracellular …

The search for new lead compounds of simple structure, displaying highest quality anti-
tumor potency with new mechanisms of action and least adverse effects is the major …

We report the synthesis and biological characterization of 3-(pyrimidin-4-yl)-7-azaindoles
(meriolins), a chemical hybrid between the natural products meridianins and variolins …

Protein kinases represent promising anticancer drug targets. We describe here the
meriolins, a new family of inhibitors of cyclin-dependent kinases (CDK). Meriolins represent …

Different series of novel pyrazole and pyrazolo [1, 5-a] pyrimidine derivatives (2a-g),(3a-
c),(7a-d) and (10a-e) were designed, synthesized and evaluated for their ability to inhibit …

Neuroblastoma (NB), the most frequent extracranial solid tumor of children accounting for
nearly 15% of all childhood cancer mortality, displays overexpression of antiapoptotic Bcl-2 …