The cyclin dependent kinases (CDKs) are a small family of serine/threonine protein kinases
that can act as a potential therapeutic target in several proliferative diseases, including …

A series of 4-(pyrazol-1-yl) carboxanilides active as inhibitors of canonical transient receptor
potential channels were synthesized in an efficient three-step protocol using controlled …

Abstract Cytochrome P450 1B1 (Cyp1b1) belongs to the CYP450 superfamily of heme-
binding mono-oxygenases which catalyze oxidation of various endogenous and exogenous …

Cyclin-dependent kinases (CDKs) and their regulators show frequent abnormalities in
tumors. Ten low molecular weight pharmacologic inhibitors of CDKs are currently in clinical …

In our ongoing search for new bioactive metabolites from microbial resources, Aspergillus
terreus (HKI0499) was examined by chemical metabolite profiling. Together with the known …

Low molecular weight cyclin E (LMW-E) plays an important oncogenic role in breast cancer.
LMW-E, which is not found in normal tissue, can promote the formation of aggressive tumors …

A one-pot synthesis of ageladine A and analogues is reported. The key Pictet− Spengler
reaction between 2-aminohistamine and aryl aldehydes has been successfully utilized for …

Go indigo: Carbohydrate derivatives of indigoid bis-indoles are effective inhibitors of several
kinases, such as CDKs and GSK-3β. Recent studies have shown that thia analogues of …

The chemical investigation of the epiphytic orchid Appendicula reflexa led to the isolation of
one new phenanthrene, 3, 4, 6, 7-tetramethoxyphenanthrene-2, 8-diol (1) and one new …

Results of a number of epidemiological and experimental studies indicate that polyphenols
(eg resveratrol (RES), epicatechins etc.), antioxidant agents and abundant micronutrients in …