Idiopathic pulmonary fibrosis and lung cancer: mechanisms and molecular targets

B Ballester, J Milara, J Cortijo - International journal of molecular sciences, 2019 - mdpi.com
Idiopathic pulmonary fibrosis (IPF) is the most common idiopathic interstitial pulmonary
disease with a median survival of 2–4 years after diagnosis. A significant number of IPF …

Current and upcoming therapies to modulate skin scarring and fibrosis

JQ Coentro, E Pugliese, G Hanley, M Raghunath… - Advanced drug delivery …, 2019 - Elsevier
Skin is the largest organ of the human body. Being the interface between the body and the
outer environment, makes it susceptible to physical injury. To maintain life, nature has …

Idiopathic pulmonary fibrosis: current status, recent progress, and emerging targets

YM Liu, K Nepali, JP Liou - Journal of medicinal chemistry, 2017 - ACS Publications
Idiopathic pulmonary fibrosis (IPF), a chronic and progressive fibrosing interstitial
pneumonia, is a fatal lung disease with a median survival time of 3–5 years. Problems in …

[HTML][HTML] Evaluation of oxidative stress biomarkers in idiopathic pulmonary fibrosis and therapeutic applications: a systematic review

AG Fois, P Paliogiannis, S Sotgia, AA Mangoni… - Respiratory …, 2018 - Springer
Introduction Idiopathic pulmonary fibrosis (IPF), a fatal lung disease of unknown origin, is
characterized by chronic and progressive fibrosing interstitial pneumonia which …

[HTML][HTML] Clinical quantification of the integrin αvβ6 by [18F]FB-A20FMDV2 positron emission tomography in healthy and fibrotic human lung (PETAL Study)

PT Lukey, C Coello, R Gunn, C Parker… - European Journal of …, 2020 - Springer
Purpose The RGD-integrin, αvβ6, plays a role in the pathogenesis of pulmonary fibrosis
through activation of transforming growth factor beta (TGFβ). This study sought to quantify …

Harnessing the role of HDAC6 in idiopathic pulmonary fibrosis: design, synthesis, structural analysis, and biological evaluation of potent inhibitors

G Campiani, C Cavella, JD Osko… - Journal of medicinal …, 2021 - ACS Publications
Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterized by a
progressive-fibrosing phenotype. IPF has been associated with aberrant HDAC activities …

[HTML][HTML] Integrins and cadherins as therapeutic targets in fibrosis

SK Agarwal - Frontiers in pharmacology, 2014 - frontiersin.org
Fibrosis is the excessive deposition of extracellular matrix proteins into tissues leading to
scar formation, disruption of normal tissue architecture and organ failure. Despite the large …

[HTML][HTML] Emodin attenuates bleomycin-induced pulmonary fibrosis via anti-inflammatory and anti-oxidative activities in rats

SL Tian, Y Yang, XL Liu, QB Xu - Medical Science Monitor …, 2018 - ncbi.nlm.nih.gov
Background Idiopathic pulmonary fibrosis (IPF) can severely damage lung function, which
may result in death. Emodin is a major ingredient of rhubarb and has been proven to protect …

Hypoxia-sensitive pathways in inflammation-driven fibrosis

MC Manresa, C Godson… - American Journal of …, 2014 - journals.physiology.org
Tissue injury can occur for a variety of reasons, including physical damage, infection, and
ischemia. The ability of tissues to effectively recover from injury is a cornerstone of human …

Discovery of 4-methylquinazoline based PI3K inhibitors for the potential treatment of idiopathic pulmonary fibrosis

S Lin, J Jin, Y Liu, H Tian, Y Zhang, R Fu… - Journal of Medicinal …, 2019 - ACS Publications
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease, and its molecular
pathogenesis remains poorly understood. Recently, emerging evidence demonstrates that …