Disturbed cholesterol homeostasis plays critical roles in the development of multiple
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …

The recommendations listed in the present guideline are, whenever possible, evidence
based. An initial extensive evidence review, which included literature derived from research …

The American Heart Association requests that this document be cited as follows: Grundy SM,
Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, Braun LT, de Ferranti S, Faiella …

There is now overwhelming evidence to support lowering LDL-c (low-density lipoprotein
cholesterol) to reduce cardiovascular morbidity and mortality. Statins are a class of drugs …

There is a need to identify high-risk features that predict early-onset atherosclerotic
cardiovascular disease (ASCVD). The authors provide insights to help clinicians identify and …

Coronary artery disease (CAD) is the most common health problem worldwide and remains
the leading cause of morbidity and mortality. Over the past decade, it has become clear that …

Atherosclerosis, a chronic multifactorial disease, is closely related to the development of
cardiovascular diseases and is one of the predominant causes of death worldwide. Normal …

Given rapid advancements in medical science, it is often challenging for the busy clinician to
remain up-to-date on the fundamental and multifaceted aspects of preventive cardiology and …

Statins are a family of drugs that are used for treating hyperlipidaemia with a recognized
capacity to prevent cardiovascular disease events. They inhibit β‐hydroxy β‐methylglutaryl …

Antisense oligonucleotides (ASOs) are promising tools for gene silencing and have been
exploited as therapeutics for human disease. However, delivery of therapeutic ASOs to …