Interleukin-2 (IL-2) is a pleiotropic cytokine produced after antigen activation that plays
pivotal roles in the immune response. Discovered as a T cell growth factor, IL-2 additionally …

Interleukin (IL)-2, IL-4, IL-7, IL-9, IL-15, and IL-21 form a family of cytokines based on their
sharing the common cytokine receptor γ chain (γc), which was originally discovered as the …

Summary The lnterleukln-2 (IL-2) receptor y chain (IL-S&) is a component of high and
Intermediate affinity IL-2 receptors that is required to achieve full ligand binding affinity and …

We have recently cloned a novel cytokine, IL‐15, with shared bioactivities but no sequence
homology with IL‐2. We found high affinity IL‐15 binding to many cell types, including cells …

Interleukin-2 (IL-2) is an immunoregulatory cytokine that acts through a quaternary receptor
signaling complex containing alpha (IL-2Rα), beta (IL-2Rβ), and common gamma chain (gc) …

Recent structural information for complexes of cytokine receptor ectodomains bound to their
ligands has significantly expanded our understanding of the macromolecular topology and …

The common γ-chain (γ c) is an indispensable subunit of the functional receptor complexes
for IL-4, IL-7, IL-9, and IL-15 as well as IL-2. Here we show that the γ c is also shared with the …

Interleukin 2 (IL-2), a T cell–derived cytokine, targets a variety of cells to induce their growth,
differentiation, and functional activation. IL-2 inserts signals into the cells through IL-2 …

Publisher Summary This chapter provides an overview of receptor activation from
biochemical and cellular studies regarding immune system development and function when …

Abstract THE interleukin-2 receptor (IL-2R) consists of three distinct chains (α, β, γ) which
bind IL-2 and generate a proliferative signal in T cells1. To define the mechanism of receptor …