Neurodegenerative diseases are a heterogeneous group of disorders that are incurable and
characterized by the progressive degeneration of the function and structure of the central …

Parkinson's disease (PD) is manifested by progressive motor, autonomic, and cognitive
disturbances. Dopamine (DA) synthesizing neurons in the substantia nigra (SN) degenerate …

The administration of reserpine to rodents was one of the first models used to investigate the
pathophysiology and screening for potential treatments of P arkinson's disease (PD). The …

Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease,
Huntington's disease, and amyotrophic lateral sclerosis are a heterogeneous group of …

Despite the different animal models of Parkinson's disease developed during the last years,
they still present limitations modelling the slow and progressive process of …

In recent years our understanding of Parkinson's disease has expanded both in terms of
pathological hallmarks as well as relevant genetic influences. In parallel with the aetiological …

Type 2 diabetes mellitus (T2DM) is a risk factor for Parkinson's disease (PD). Therefore,
treatment to improve insulin resistance in T2DM may be useful for PD patients. Glucose …

Parkinson disease (PD) is the second most common form of neurodegeneration among
elderly individuals. PD is clinically characterized by tremors, rigidity, slowness of movement …

Abstract The neurotoxin 6-hydroxydopamine (6-OHDA), following pretreatment with the
norepinephrine transport inhibitor desipramine, selectively destroys dopaminergic neurons …

Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) are a common genetic
cause of Parkinson disease, but the mechanisms whereby LRRK2 is regulated are …