The probabilistic model of Alzheimer disease: the amyloid hypothesis revised
The current conceptualization of Alzheimer disease (AD) is driven by the amyloid
hypothesis, in which a deterministic chain of events leads from amyloid deposition and then …
hypothesis, in which a deterministic chain of events leads from amyloid deposition and then …
Recent update on the heterogeneity of the Alzheimer's disease spectrum
KA Jellinger - Journal of Neural Transmission, 2022 - Springer
Abstract Alzheimer's disease (AD), the most common form of dementia worldwide, is a mixed
proteinopathy (β-amyloid, tau and other proteins). Classically defined as a …
proteinopathy (β-amyloid, tau and other proteins). Classically defined as a …
Increased medial temporal tau positron emission tomography uptake in the absence of amyloid-β positivity
A Costoya-Sánchez, A Moscoso… - JAMA …, 2023 - jamanetwork.com
Importance An increased tau positron emission tomography (PET) signal in the medial
temporal lobe (MTL) has been observed in older individuals in the absence of amyloid-β …
temporal lobe (MTL) has been observed in older individuals in the absence of amyloid-β …
ApoE4 and connectivity-mediated spreading of tau pathology at lower amyloid levels
Importance For the Alzheimer disease (AD) therapies to effectively attenuate clinical
progression, it may be critical to intervene before the onset of amyloid-associated tau …
progression, it may be critical to intervene before the onset of amyloid-associated tau …
The complex pathway between amyloid β and cognition: implications for therapy
For decades, the hypothesis that brain deposition of the amyloid β protein initiates
Alzheimer's disease has dominated research and clinical trials. Targeting amyloid β is …
Alzheimer's disease has dominated research and clinical trials. Targeting amyloid β is …
Age-related and amyloid-beta-independent tau deposition and its downstream effects
Amyloid-β (Aβ) is hypothesized to facilitate the spread of tau pathology beyond the medial
temporal lobe. However, there is evidence that, independently of Aβ, age-related tau …
temporal lobe. However, there is evidence that, independently of Aβ, age-related tau …
18F-FDG PET imaging in neurodegenerative dementing disorders: insights into subtype classification, emerging disease categories, and mixed dementia with …
S Minoshima, D Cross, T Thientunyakit… - Journal of Nuclear …, 2022 - Soc Nuclear Med
Since the invention of 18 F-FDG as a neurochemical tracer in the 1970s, 18 F-FDG PET has
been used extensively for dementia research and clinical applications. FDG, a glucose …
been used extensively for dementia research and clinical applications. FDG, a glucose …
Cerebrovascular disease promotes tau pathology in Alzheimer's disease
Small vessel cerebrovascular disease, visualized as white matter hyperintensities on T2-
weighted magnetic resonance imaging, contributes to the clinical presentation of …
weighted magnetic resonance imaging, contributes to the clinical presentation of …
Application of the ATN classification scheme in a population without dementia: Findings from the EPAD cohort
S Ingala, C De Boer, LA Masselink… - Alzheimer's & …, 2021 - Wiley Online Library
Background We classified non‐demented European Prevention of Alzheimer's Dementia
(EPAD) participants through the amyloid/tau/neurodegeneration (ATN) scheme and …
(EPAD) participants through the amyloid/tau/neurodegeneration (ATN) scheme and …
Relevance of biomarkers across different neurodegenerative diseases
AJ Ehrenberg, A Khatun, E Coomans, MJ Betts… - Alzheimer's research & …, 2020 - Springer
Background The panel of fluid-and imaging-based biomarkers available for
neurodegenerative disease research is growing and has the potential to close important …
neurodegenerative disease research is growing and has the potential to close important …