Difficult asthma is a heterogeneous disease of the airways including various types of
bronchial inflammation and various degrees of airway remodeling. Therapeutic response of …

Background Bronchial thermoplasty (BT) is a non-pharmacological intervention for severe
asthma whose mechanism of action is not completely explained by a reduction of airway …

Although a small proportion of patients with asthma have severe disease, it accounts for the
majority of morbidity related to the illness. Severe asthma comprises a heterogeneous group …

Bronchial thermoplasty is a young yet promising treatment for severe asthma whose benefit
for long-term asthma control outweighs the short-term risk of deterioration and …

Asthma characterizes a complex syndrome manifested by airway obstruction, inflammation,
and hyperresponsiveness. Contemporary thought suggests that patients with asthma exhibit …

Background Phenotypes and endotypes predicting optimal response to bronchial
thermoplasty (BT) in patients with severe asthma remain elusive. Objective Our aim was to …

Background: Asthma has an important impact in terms of both direct and indirect costs. In
Europe, the disease costs€ 19 000 million a year. Moreover, the cost is greater among …

Magnetic resonance imaging (MRI) is a potentially ideal imaging modality for noninvasive,
nonionizing, and longitudinal assessment of disease. Hyperpolarized (HP) agents have …

Introduction Bronchial thermoplasty is an effective intervention to improve respiratory
symptoms and to reduce the rate of exacerbations in uncontrolled severe asthma. A …

Inhaled corticosteroids are the mainstay of asthma treatment using a step-up approach with
incremental dosing and additional controller medications in order to achieve symptom …