The cell microenvironment has emerged as a key determinant of cell behavior and function
in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the …

Cardiovascular diseases remain the leading cause of human mortality worldwide. Some
severe symptoms, including myocardial infarction and heart failure, are difficult to heal …

In the past few years, a considerable amount of effort has been devoted toward the
development of biomimetic scaffolds for cardiac tissue engineering. However, most of the …

Access to robust and information-rich human cardiac tissue models would accelerate drug-
based strategies for treating heart disease. Despite significant effort, the generation of high …

Biodegradable tissue engineering scaffolds have great potential for delivering
cells/therapeutics and supporting tissue formation. Polyesters, the most extensively …

Corneal diseases constitute the second leading cause of vision loss and affect more than 10
million people globally. As there is a severe shortage of fresh donated corneas and an …

One of the obstacles in studying the pathogenesis of hypertrophic cardiomyopathy (HCM) is
the poor availability of myocardial tissue samples at the early stages of disease …

Biomaterials to facilitate the restoration of cardiac tissue is of emerging importance. While
there are many aspects to consider in the design of biomaterials, mechanical properties can …

Aim: To evaluate the efficacy of electrically conductive, biocompatible composite scaffolds in
modulating the cardiomyogenic differentiation of human mesenchymal stem cells (hMSCs) …

A decade ago, stem or progenitor cells held the promise of tissue regeneration in human
myocardium, with the expectation that these therapies could rescue ischemic myocyte …