Tumor temperature: friend or foe of virus-based cancer immunotherapy
JP Knapp, JE Kakish, BW Bridle, DJ Speicher - Biomedicines, 2022 - mdpi.com
The temperature of a solid tumor is often dissimilar to baseline body temperature and,
compared to healthy tissues, may be elevated, reduced, or a mix of both. The temperature of …
compared to healthy tissues, may be elevated, reduced, or a mix of both. The temperature of …
The potential of cold-shock promoters for the expression of recombinant proteins in microbes and mammalian cells
Y Bartolo-Aguilar, C Chávez-Cabrera… - Journal of Genetic …, 2022 - Springer
Background Low-temperature expression of recombinant proteins may be advantageous to
support their proper folding and preserve bioactivity. The generation of expression vectors …
support their proper folding and preserve bioactivity. The generation of expression vectors …
Pharmacokinetics during therapeutic hypothermia in neonates: from pathophysiology to translational knowledge and physiologically-based pharmacokinetic (PBPK) …
K Leys, MS Stroe, P Annaert… - Expert opinion on …, 2023 - Taylor & Francis
Introduction Perinatal asphyxia (PA) still causes significant morbidity and mortality.
Therapeutic hypothermia (TH) is the only effective therapy for neonates with moderate to …
Therapeutic hypothermia (TH) is the only effective therapy for neonates with moderate to …
Listeria monocytogenes Cold Shock Proteins: Small Proteins with A Huge Impact
F Muchaamba, R Stephan, T Tasara - Microorganisms, 2021 - mdpi.com
Listeria monocytogenes has evolved an extensive array of mechanisms for coping with
stress and adapting to changing environmental conditions, ensuring its virulence phenotype …
stress and adapting to changing environmental conditions, ensuring its virulence phenotype …
Drug delivery approaches for HuR-targeted therapy for lung cancer
Lung cancer (LC) is often diagnosed at an advanced stage and conventional treatments for
disease management have limitations associated with them. Novel therapeutic targets are …
disease management have limitations associated with them. Novel therapeutic targets are …
Silencing circSERPINE2 restrains mesenchymal stem cell senescence via the YBX3/PCNA/p21 axis
F Chen, S Wang, C Zeng, S Tang, H Gu… - Cellular and Molecular …, 2023 - Springer
Increasing evidence indicates that circular RNAs (circRNAs) accumulate in aging tissues
and nonproliferating cells due to their high stability. However, whether upregulation of …
and nonproliferating cells due to their high stability. However, whether upregulation of …
The Glycine-Rich RNA-Binding Protein Is a Vital Post-Transcriptional Regulator in Crops
K Cheng, C Zhang, Y Lu, J Li, H Tang, L Ma, H Zhu - Plants, 2023 - mdpi.com
Glycine-rich RNA binding proteins (GR-RBPs), a branch of RNA binding proteins (RBPs),
play integral roles in regulating various aspects of RNA metabolism regulation, such as RNA …
play integral roles in regulating various aspects of RNA metabolism regulation, such as RNA …
Poised PABP–RNA hubs implement signal-dependent mRNA decay in development
Signaling pathways drive cell fate transitions largely by changing gene expression.
However, the mechanisms for rapid and selective transcriptome rewiring in response to …
However, the mechanisms for rapid and selective transcriptome rewiring in response to …
Novel insights into YB-1 signaling and cell death decisions
A Shah, JA Lindquist, L Rosendahl, I Schmitz… - Cancers, 2021 - mdpi.com
Simple Summary Signals that determine cell survival or death are essential for maintaining
tissue homeostasis. Cell death promotes the removal of unwanted cells; however, a failure …
tissue homeostasis. Cell death promotes the removal of unwanted cells; however, a failure …
β-barrels and amyloids: Structural transitions, biological functions, and pathogenesis
AI Sulatskaya, AO Kosolapova, AG Bobylev… - International Journal of …, 2021 - mdpi.com
Insoluble protein aggregates with fibrillar morphology called amyloids and β-barrel proteins
both share a β-sheet-rich structure. Correctly folded β-barrel proteins can not only function in …
both share a β-sheet-rich structure. Correctly folded β-barrel proteins can not only function in …