Peroxisome biogenesis, membrane contact sites, and quality control
Peroxisomes are conserved organelles of eukaryotic cells with important roles in cellular
metabolism, human health, redox homeostasis, as well as intracellular metabolite transfer …
metabolism, human health, redox homeostasis, as well as intracellular metabolite transfer …
The industrial yeast Pichia pastoris is converted from a heterotroph into an autotroph capable of growth on CO2
The methylotrophic yeast Pichia pastoris is widely used in the manufacture of industrial
enzymes and pharmaceuticals. Like most biotechnological production hosts, P. pastoris is …
enzymes and pharmaceuticals. Like most biotechnological production hosts, P. pastoris is …
The peroxisome biogenesis factors Pex3 and Pex19: multitasking proteins with disputed functions
RLM Jansen, IJ van der Klei - FEBS letters, 2019 - Wiley Online Library
The peroxisomal membrane protein (PMP) Pex3 and its cytosolic interaction partner Pex19
have been implicated in peroxisomal membrane biogenesis. Although these peroxins have …
have been implicated in peroxisomal membrane biogenesis. Although these peroxins have …
ESCRT-III is required for scissioning new peroxisomes from the endoplasmic reticulum
FD Mast, T Herricks, KM Strehler, LR Miller… - Journal of Cell …, 2018 - rupress.org
Dynamic control of peroxisome proliferation is integral to the peroxisome's many functions.
The endoplasmic reticulum (ER) serves as a source of preperoxisomal vesicles (PPVs) that …
The endoplasmic reticulum (ER) serves as a source of preperoxisomal vesicles (PPVs) that …
[HTML][HTML] Fatty Liver Due to Increased de novo Lipogenesis: Alterations in the Hepatic Peroxisomal Proteome
B Knebel, P Fahlbusch, M Dille, N Wahlers… - Frontiers in Cell and …, 2019 - frontiersin.org
In non-alcoholic fatty liver disease (NAFLD) caused by ectopic lipid accumulation,
lipotoxicity is a crucial molecular risk factor. Mechanisms to eliminate lipid overflow can …
lipotoxicity is a crucial molecular risk factor. Mechanisms to eliminate lipid overflow can …
Peroxisomes contribute to oxidative stress in neurons during doxorubicin-based chemotherapy
JF Moruno-Manchon, NE Uzor, SR Kesler… - Molecular and Cellular …, 2018 - Elsevier
Doxorubicin, a commonly used anti-neoplastic agent, causes severe neurotoxicity.
Doxorubicin promotes thinning of the brain cortex and accelerates brain aging, leading to …
Doxorubicin promotes thinning of the brain cortex and accelerates brain aging, leading to …
Melatonin-Nrf2 signaling activates peroxisomal activities in porcine cumulus cell-oocyte complexes
Melatonin and Nrf2 signaling synergistically improve mammalian oocyte maturation and
embryonic development. Furthermore, previous studies have suggested an interplay …
embryonic development. Furthermore, previous studies have suggested an interplay …
A new yeast peroxin, Pex36, a functional homolog of mammalian PEX16, functions in the ER-to-peroxisome traffic of peroxisomal membrane proteins
Peroxisomal membrane proteins (PMPs) traffic to peroxisomes by two mechanisms: direct
insertion from the cytosol into the peroxisomal membrane and indirect trafficking to …
insertion from the cytosol into the peroxisomal membrane and indirect trafficking to …
Peroxisome-based metabolic engineering for biomanufacturing and agriculture
Subcellular compartmentalization of metabolic pathways plays a crucial role in metabolic
engineering. The peroxisome has emerged as a highly valuable and promising …
engineering. The peroxisome has emerged as a highly valuable and promising …
Peroxisome prognostications: Exploring the birth, life, and death of an organelle
Peroxisomes play a central role in human health and have biochemical properties that
promote their use in many biotechnology settings. With a primary role in lipid metabolism …
promote their use in many biotechnology settings. With a primary role in lipid metabolism …