The CNS critically relies on the formation and proper function of its vasculature during
development, adult homeostasis and disease. Angiogenesis—the formation of new blood …

Intracerebral hemorrhage (ICH) accounts for a disproportionate amount of stroke-related
morbidity and mortality. Although chronic hypertension and cerebral amyloid angiopathy are …

Cerebrovascular diseases are a leading cause of death and neurologic disability. Further
understanding of disease mechanisms and therapeutic strategies requires a deeper …

Minimally invasive transcatheter embolization is a common nonsurgical procedure in
interventional radiology used for the deliberate occlusion of blood vessels for the treatment …

Brain arteriovenous malformations (AVMs) are anomalous direct shunts between cerebral
arteries and veins that convalesce into a vascular nidus. The treatment strategies for AVMs …

Stroke is an important cause of neurological morbidity in children; most survivors have
permanent neurological deficits that affect the remainder of their life. Stroke in childhood, the …

Rationale: We previously identified somatic activating mutations in the KRAS (Kirsten rat
sarcoma viral oncogene homologue) gene in the endothelium of the majority of human …

The vasculature is increasingly recognized to impact brain function in health and disease
across the life span. During embryonic brain development, angiogenesis and neurogenesis …

OBJECTIVE Brain arteriovenous malformations (bAVMs) are rupture-prone tangles of blood
vessels with direct shunting of blood flow between arterial and venous circulations. The …

Importance The dilemma between natural rupture risk and adverse outcomes of intervention
is of major concern for patients with unruptured arteriovenous malformations (AVMs). The …