Panax ginseng against myocardial ischemia/reperfusion injury: A review of preclinical evidence and potential mechanisms

J Chen, Q Huang, J Li, Y Yao, W Sun, Z Zhang… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance Panax ginseng CA Meyer (P. ginseng) is effective in the
prevention and treatment of myocardial ischemia-reperfusion (I/R) injury. The mechanism by …

Role of oxidative stress in cardiac dysfunction and subcellular defects due to ischemia-reperfusion injury

NS Dhalla, AK Shah, A Adameova, M Bartekova - Biomedicines, 2022 - mdpi.com
Ischemia-reperfusion (I/R) injury is well-known to be associated with impaired cardiac
function, massive arrhythmias, marked alterations in cardiac metabolism and irreversible …

Inhibition of myocardial cell apoptosis is important mechanism for ginsenoside in the limitation of myocardial ischemia/reperfusion injury

Z Chen, J Wu, S Li, C Liu, Y Ren - Frontiers in Pharmacology, 2022 - frontiersin.org
Ischemic heart disease has a high mortality, and the recommended therapy is reperfusion.
Nevertheless, the restoration of blood flow to ischemic tissue leads to further damage …

Blockage of Fibronectin 1 Ameliorates Myocardial Ischemia/Reperfusion Injury in Association with Activation of AMP‐LKB1‐AMPK Signaling Pathway

YL Zhang, PB Li, X Han, B Zhang… - Oxidative Medicine and …, 2022 - Wiley Online Library
Myocardial ischemia/reperfusion injury (I/RI) is closely associated with energy substrate
metabolism. Fibronectin 1 (Fn1) was markedly elevated in the heart of I/R pigs and ischemic …

Ketone ester supplementation suppresses cardiac inflammation and improves cardiac energetics in a swine model of acute myocardial infarction

SR Yurista, RA Eder, A Welsh, W Jiang, S Chen… - Metabolism, 2023 - Elsevier
Background Myocardial infarction (MI) is a major risk factor for the development of heart
failure with reduce ejection fraction (HFrEF). While previous studies have focused on HFrEF …

Dynamic Metabolic Changes During Prolonged Ex Situ Heart Perfusion Are Associated With Myocardial Functional Decline

M Olkowicz, RVP Ribeiro, F Yu, JS Alvarez… - Frontiers in …, 2022 - frontiersin.org
Ex situ heart perfusion (ESHP) was developed to preserve and evaluate donated hearts in a
perfused beating state. However, myocardial function declines during ESHP, which limits the …

Cardioprotective Effect of circ_SMG6 Knockdown against Myocardial Ischemia/Reperfusion Injury Correlates with miR‐138‐5p‐Mediated EGR1/TLR4/TRIF …

C Huang, Y Qu, F Feng, H Zhang, L Shu… - Oxidative Medicine …, 2022 - Wiley Online Library
Increased neutrophil recruitment represents a hallmark event in myocardial
ischemia/reperfusion (I/R) injury due to the ensuing inflammatory response. Circular RNAs …

Promising therapeutic candidate for myocardial ischemia/reperfusion injury: what are the possible mechanisms and roles of phytochemicals?

C Chen, LT Yu, BR Cheng, JL Xu, Y Cai… - Frontiers in …, 2022 - frontiersin.org
Percutaneous coronary intervention (PCI) is one of the most effective reperfusion strategies
for acute myocardial infarction (AMI) despite myocardial ischemia/reperfusion (I/R) injury …

Role of the antioxidant activity of melatonin in myocardial ischemia-reperfusion injury

JL Bermudez-Gonzalez, D Sanchez-Quintero… - Antioxidants, 2022 - mdpi.com
Ischemia-reperfusion injury is a common problem in the age of interventional cardiology; it is
primarily mediated by oxidative stress and reactive agents. Melatonin has antioxidative …

[HTML][HTML] Powering Prescription: Mitochondria as “Living Drugs”-Definition, Clinical Applications, and Industry Advancements

A Caicedo, E Morales, A Moyano, S Peñaherrera… - Pharmacological …, 2023 - Elsevier
Mitochondria's role as engines and beacons of metabolism and determinants of cellular
health is being redefined through their therapeutic application as “Living Drugs”(LDs) …