Sensing, responding, and adapting to the surrounding environment are crucial for all living
organisms to survive, proliferate, and differentiate in their biological niches. This ability is …

The gateway to the secretory pathway is the endoplasmic reticulum (ER), an organelle that
is responsible for the accurate folding, post-translational modification and final assembly of …

A common feature shared by systemic fungal pathogens of environmental origin, such as
Cryptococcus neoformans, is their ability to adapt to mammalian core body temperature. In …

Heteroresistance in Cryptococcus neoformans is an intrinsic adaptive resistance to azoles
and the heteroresistant phenotype is associated with disomic chromosomes. Two …

Cryptococcus neoformans is one of the few environmental fungi that can survive within a
mammalian host and cause disease. Although many of the factors responsible for …

Aspergillus fumigatus is an opportunistic pathogen that is responsible for a life-threatening
fungal infection known as invasive aspergillosis. Current therapies for the treatment of this …

The pathogenic fungus C ryptococcus neoformans must overcome multiple stressors to
cause disease in its human host. In this study, we report that C. neoformans rapidly and …

Unique and evolutionarily conserved signaling pathways allow an organism to sense,
respond to, and adapt to internal and external environmental cues at its biological niche. In …

The capacity of opportunistic fungal pathogens such as Cryptococcus neoformans to cause
disease is dependent on their ability to overcome an onslaught of stresses including …

Pathogenic fungal species can cause superficial and mucosal surface infections, to
potentially fatal systemic or invasive infections in humans. These infections are more …