The cell walls of fungi are critical for cellular structure and rigidity but also serve as a major
communicator to alert the cell to the changing environment. In response to stresses …

Pathogenic fungal species can cause superficial and mucosal surface infections, to
potentially fatal systemic or invasive infections in humans. These infections are more …

Accumulation of misfolded proteins in the endoplasmic reticulum (ER) activates the unfolded
protein response (UPR). Here, we investigated how the target of rapamycin complex 1 …

The endoplasmic reticulum (ER) responds to errors in protein folding or processing by
induction of the unfolded protein response (UPR). During conditions of ER stress …

In all eukaryotic cells, the ER stress response is pivotal to survival and adaptation under
stress conditions. During temperature adaptation in the human fungal pathogen …

In Cryptococcus neoformans, mRNAs encoding ribosomal proteins (RP) are rapidly and
specifically repressed during cellular stress, and the bulk of this repression is mediated by …

The development of RNA imaging techniques and the establishment of systems biology
approaches, together with the improvement of large-scale RNA-protein crosslinking …

The unfolded protein response (UPR) is induced when the quality control machinery of the
cell is overloaded with unfolded proteins or when one of the functions of the endoplasmic …

Opportunistic pathogens like Cryptococcus neoformans are constantly exposed to changing
environments, in their natural habitat as well as when encountering a human host. This …

This chapter presents Cryptococcus neoformans, an important model human fungal
pathogen, with a focus on sexual reproduction and morphogenesis given that they play key …