[HTML][HTML] The interaction between ferroptosis and lipid metabolism in cancer

D Li, Y Li - Signal transduction and targeted therapy, 2020 - nature.com
Ferroptosis is a new form of programmed cell death characterized by the accumulation of
iron-dependent lethal lipid peroxides. Recent discoveries have focused on alterations that …

[HTML][HTML] A novel ferroptosis-related gene signature for overall survival prediction in patients with hepatocellular carcinoma

J Liang, D Wang, H Lin, X Chen, H Yang… - … journal of biological …, 2020 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is a highly heterogeneous disease, which makes the
prognostic prediction challenging. Ferroptosis, an iron-dependent form of regulated cell …

Ferroptosis, radiotherapy, and combination therapeutic strategies

G Lei, C Mao, Y Yan, L Zhuang, B Gan - Protein & cell, 2021 - academic.oup.com
Ferroptosis, an iron-dependent form of regulated cell death driven by peroxidative damages
of polyunsaturated-fatty-acid-containing phospholipids in cellular membranes, has recently …

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

K Bersuker, JM Hendricks, Z Li, L Magtanong, B Ford… - Nature, 2019 - nature.com
Ferroptosis is a form of regulated cell death that is caused by the iron-dependent
peroxidation of lipids,. The glutathione-dependent lipid hydroperoxidase glutathione …

GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis

DM Kremer, BS Nelson, L Lin, EL Yarosz… - Nature …, 2021 - nature.com
Cancer metabolism is rewired to support cell survival in response to intrinsic and
environmental stressors. Identification of strategies to target these adaptions is an area of …

Persister cancer cells: Iron addiction and vulnerability to ferroptosis

R Rodriguez, SL Schreiber, M Conrad - Molecular cell, 2022 - cell.com
Ferroptosis is a unique type of non-apoptotic cell death resulting from the unrestrained
occurrence of peroxidized phospholipids, which are subject to iron-mediated production of …

Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11

X Lang, MD Green, W Wang, J Yu, JE Choi, L Jiang… - Cancer discovery, 2019 - AACR
A challenge in oncology is to rationally and effectively integrate immunotherapy with
traditional modalities, including radiotherapy. Here, we demonstrate that radiotherapy …

Ferroptosis and its potential role in the physiopathology of Parkinson's Disease

L Mahoney-Sánchez, H Bouchaoui, S Ayton… - Progress in …, 2021 - Elsevier
Parkinson's Disease (PD) is a common and progressive neurodegenerative disorder
characterised by motor impairments as well as non-motor symptoms. While dopamine …

Ferroptosis detection: from approaches to applications

F Zeng, S Nijiati, L Tang, J Ye, Z Zhou… - Angewandte …, 2023 - Wiley Online Library
Understanding the intricate molecular machinery that governs ferroptosis and leveraging
this accumulating knowledge could facilitate disease prevention, diagnosis, treatment, and …

HCAR1/MCT1 regulates tumor ferroptosis through the lactate-mediated AMPK-SCD1 activity and its therapeutic implications

Y Zhao, M Li, X Yao, Y Fei, Z Lin, Z Li, K Cai, Y Zhao… - Cell reports, 2020 - cell.com
Ferroptosis is a recently discovered form of programed cell death caused by the
metabolically regulated lipid peroxidation and holds promise for cancer treatment, but its …