Simple Summary The dysregulation of ACSL3 and ACSL4, which belong to the long-chain
fatty acyl CoA synthetase family (ACSLs), affects the behavior of various cancer cells. This …

Ferroptosis is associated with lipid hydroperoxides generated by the oxidation of
polyunsaturated acyl chains. Lipid hydroperoxides are reduced by glutathione peroxidase 4 …

Ferroptosis is a recently described form of cell death driven by iron-dependent lipid
peroxidation. This type of cell death was first observed in response to treatment of tumor …

Ferroptosis is a type of regulated necrosis that is triggered by a combination of iron toxicity,
lipid peroxidation, and plasma membrane damage. The upstream inducers of ferroptosis …

Ferroptosis is a new form of regulated cell death (RCD) driven by iron-dependent lipid
peroxidation, which is morphologically and mechanistically distinct from other forms of RCD …

Apoptosis, the first regulated form of cell death discovered in mammalian cells, is executed
by caspase-3/7, which are dormant in living cells but become activated by upstream …

It is well established that ferroptosis is primarily induced by peroxidation of long-chain poly-
unsaturated fatty acid (PUFA) through nonenzymatic oxidation by free radicals or enzymatic …

Lipid droplets are dynamic intracellular lipid storage organelles that respond to the
physiological state of cells. In addition to controlling cell metabolism, they play a protective …

Ferroptosis, a regulated cell death pathway driven by accumulation of phospholipid
peroxides, has been challenging to identify in physiological conditions owing to the lack of a …

Metastasis formation is a complex process, involving multiple crucial steps, which are
controlled by different regulatory mechanisms. In this context, the contribution of cancer …