Iron is vital for many physiological functions, including energy production, and dysregulated
iron homeostasis underlies a number of pathologies. Ferroptosis is a recently recognized …

Concurrent loss-of-function mutations in STK11 and KEAP1 in lung adenocarcinoma
(LUAD) are associated with aggressive tumor growth, resistance to available therapies, and …

Cardiovascular disease (CVD) is a major contributor to increasing morbidity and mortality
worldwide and seriously threatens human health and life. Cardiomyocyte death is …

Tumor cellular metabolism exhibits distinguishing features that collectively enhance
biomass synthesis while maintaining redox balance and cellular homeostasis. These …

Glioblastoma (GBM) is a primary tumor of the brain defined by its uniform lethality and
resistance to conventional therapies. There have been considerable efforts to untangle the …

Dietary lipids impact development, homeostasis, and disease, but links between specific
dietary fats and cell fates are poorly understood. Ferroptosis is an iron-dependent form of …

In advanced atherosclerosis (AS), defective function-induced cell death leads to the
formation of the characteristic necrotic core and vulnerable plaque. The forms and …

Allelic variation to the APOE gene confers the greatest genetic risk for sporadic Alzheimer's
disease (AD). Independent of genotype, low abundance of apolipoprotein E (apoE), is …

Ferroptosis is a type of regulated cell death characterized by an excessive lipid peroxidation
of cellular membranes caused by the disruption of the antioxidant defense system and/or an …

Lipid droplets are dynamic organelles that store neutral lipids, serve the metabolic needs of
cells, and sequester lipids to prevent lipotoxicity and membrane damage. Here we review …