Induction and application of ferroptosis in cancer therapy
Q Nie, Y Hu, X Yu, X Li, X Fang - Cancer Cell International, 2022 - Springer
At present, more than one cell death pathways have been found, one of which is ferroptosis.
Ferroptosis was discovered in 2012 and described as an iron-dependent and lipid …
Ferroptosis was discovered in 2012 and described as an iron-dependent and lipid …
Ferroptosis of immune cells in the tumor microenvironment
R Kim, D Taylor, RH Vonderheide… - Trends in …, 2023 - cell.com
Ferroptosis is a distinct form of cell death driven by the accumulation of peroxidized lipids.
Characterized by alterations in redox lipid metabolism, ferroptosis has been implicated in a …
Characterized by alterations in redox lipid metabolism, ferroptosis has been implicated in a …
An integrated view of lipid metabolism in ferroptosis revisited via lipidomic analysis
Ferroptosis is a form of regulated cell death characterized by iron-dependent lipid
peroxidation. This process contributes to cellular and tissue damage in various human …
peroxidation. This process contributes to cellular and tissue damage in various human …
The metabolic underpinnings of ferroptosis
J Zheng, M Conrad - Cell metabolism, 2020 - cell.com
Acute or chronic cellular stress resulting from aberrant metabolic and biochemical processes
may trigger a pervasive non-apoptotic form of cell death, generally known as ferroptosis …
may trigger a pervasive non-apoptotic form of cell death, generally known as ferroptosis …
Targeting ferroptosis by poly(acrylic) acid coated Mn3O4 nanoparticles alleviates acute liver injury
X Shan, J Li, J Liu, B Feng, T Zhang, Q Liu… - Nature …, 2023 - nature.com
Ferroptosis, a newly characterized form of regulated cell death, is induced by excessive
accumulation of lipid peroxidation catalyzed by intracellular bioactive iron. Increasing …
accumulation of lipid peroxidation catalyzed by intracellular bioactive iron. Increasing …
Strategies to reduce the risks of mRNA drug and vaccine toxicity
D Bitounis, E Jacquinet, MA Rogers… - Nature Reviews Drug …, 2024 - nature.com
Abstract mRNA formulated with lipid nanoparticles is a transformative technology that has
enabled the rapid development and administration of billions of coronavirus disease 2019 …
enabled the rapid development and administration of billions of coronavirus disease 2019 …
Ferroptosis in Parkinson's disease: Molecular mechanisms and therapeutic potential
X Ding, L Gao, Z Han, S Eleuteri, W Shi, Y Shen… - Ageing research …, 2023 - Elsevier
Parkinson's Disease (PD) is characterized by the progressive loss of dopaminergic neurons
in the substantia nigra (SN), leading to motor and non-motor symptoms. While the exact …
in the substantia nigra (SN), leading to motor and non-motor symptoms. While the exact …
Targeting ferroptosis in pancreatic cancer: a double-edged sword
Pancreatic ductal adenocarcinoma (PDAC) remains an aggressive malignancy with a 5-year
survival rate below 10%. Its unique genetic makeup and tumor microenvironment produce a …
survival rate below 10%. Its unique genetic makeup and tumor microenvironment produce a …
Iron and cancer: 2020 vision
SV Torti, FM Torti - Cancer research, 2020 - AACR
New and provocative insights into the relationships between iron and cancer have been
uncovered in recent years. These include delineation of connections that link cellular iron to …
uncovered in recent years. These include delineation of connections that link cellular iron to …
The molecular mechanisms of iron metabolism and its role in cardiac dysfunction and cardioprotection
T Ravingerová, L Kindernay, M Barteková… - International journal of …, 2020 - mdpi.com
Iron is an essential mineral participating in different functions of the organism under
physiological conditions. Numerous biological processes, such as oxygen and lipid …
physiological conditions. Numerous biological processes, such as oxygen and lipid …